Results 31 to 40 of about 2,476,356 (396)

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting [PDF]

, 2000
PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Couet, W., Dufès, Christine, Gray, A.I., Olivier, J.C., Schätzlein, A.G., Tetley, L., Uchegbu, I.F., Watson, D.G.   +7 more
core   +1 more source

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

Haematologica, 2010
Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.
Maura Poli, Sara Luscieti, Valentina Gandini, Federica Maccarinelli, Dario Finazzi, Laura Silvestri, Antonella Roetto, Paolo Arosio   +7 more
doaj   +1 more source

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Magez, Stefan, Stijlemans, Benoit   +2 more
core   +2 more sources

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

Cell Death and Disease, 2019
Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of autophagy has been suggested during ferroptosis.
Eunhee Park, S. Chung
semanticscholar   +1 more source

Transferrin receptor 1 is a cellular receptor for human heme-albumin

Communications Biology, 2020
Iron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.
Brell Jennifer, Verena Berg, Madhura Modak, A. Puck, Maria Seyerl‐Jiresch, Sarojinidevi Künig, G. Zlabinger, P. Steinberger, J. Chou, R. Geha, L. Öhler, A. Yachie, H. Choe, M. Kraller, H. Stockinger, J. Stöckl   +15 more
semanticscholar   +1 more source

The contribution of diet and genotype to iron status in women:a classical twin study [PDF]

, 2013
This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in ...
Alexander J. Macgregor, AM Minihane, Ana M. Valdes, Ana Paula Arez, Anna A. Wawer, B Benyamin, B Lonnerdal, B Teucher, BA Thompson, CE McLaren, D Gaitán, G Rybo, Geoffrey R. Guile, Jane Skinner, JB Whitfield, JB Whitfield, JD Cook, JN Feder, K Oexle, L Almasy, L Hallberg, LJ Harvey, OM Visscher, R Hurrell, Rachel Hurst, SA Bingham, SJ Thorpe, Susan J. Fairweather-Tait   +27 more
core   +9 more sources

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

Molecular Therapy: Nucleic Acids, 2012
The transferrin receptor, CD71, is an attractive target for drug development because of its high expression on a number of cancer cell lines and the blood brain barrier. To generate serum-stabilized aptamers that recognize the human transferrin receptor,
Samantha E Wilner, Brian Wengerter, Keith Maier, Maria de Lourdes Borba Magalhães, David Soriano Del Amo, Supriya Pai, Felipe Opazo, Silvio O Rizzoli, Amy Yan, Matthew Levy   +9 more
doaj   +1 more source

The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes

Journal of Lipid Research, 2022
The low-density lipoprotein receptor (LDLR) mediates the hepatic uptake of circulating low-density lipoproteins (LDLs), a process that modulates the development of atherosclerotic cardiovascular disease.
Taslima Gani Khan, David Ginsburg, Brian T. Emmer   +2 more
doaj   +1 more source

Transferrin-polycation-DNA complexes. The effect of polycations on the structure of the complex and DNA delivery to cells. [PDF]

, 1991
We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates.
Birnstiel, Max L., Cotten, Matt, Foisner, Roland, Wagner, Ernst   +3 more
core   +2 more sources

Structure of the Human Transferrin Receptor-Transferrin Complex [PDF]

Cell, 2004
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of
Cheng, Yifan, Zak, Olga, Aisen, Philip, Harrison, Stephen C, Walz, Thomas   +4 more
openaire   +2 more sources