Results 11 to 20 of about 234,812 (200)

THU0271 SERUM LEVELS OF TRANSFORMING GROWTH FACTOR î‘ (TGF-î‘) IN PATIENTS WITH PRIMARY SJÖGREN'S SYNDROME [PDF]

Annals of the Rheumatic Diseases, 2019
Background Primary Sjogren’s syndrome (pSS) is an autoimmune disease affecting primarily exocrine, especially salivary, glands. The epithelial damage, autoantigens release, activation of innate and acquired immunity form the underlaying of the pSS pathogenesis. The main role in pSS is played by B-lymphocytes and production of autoantibodies.
Maria Maślińska, Agnieszka Paradowska-Gorycka, Małgorzata Mańczak, Kinga Kostyra-Grabczak, Brygida Kwiatkowska   +4 more
openaire   +1 more source

TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

BMC Musculoskeletal Disorders, 2021
Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans.
Yuji Yokozeki, Kentaro Uchida, Ayumu Kawakubo, Mitsufumi Nakawaki, Tadashi Okubo, Masayuki Miyagi, Gen Inoue, Makoto Itakura, Hiroyuki Sekiguchi, Masashi Takaso   +9 more
doaj   +1 more source

Correlation of Expression Transforming Growth Factor-β1, E-cadherin, and Ki-67 in Meningiomas

Open Access Macedonian Journal of Medical Sciences, 2020
BACKGROUND: Meningioma is the most common primary intracranial tumors in adults, accounts for 36% of total intracranial tumors. Obtaining the clinicopathological characteristics of patients with meningioma and investigating, the association between signaling pathways with disease progression could provide a basis for therapeutic development.AIM: This ...
Apriyanto, Apriyanto, Darwin, Eryati, Arifin, Muhammad Z., Harahap, Wirsma A.   +3 more
openaire   +2 more sources

Regulation of the transforming growth factor β pathway by reversible ubiquitylation [PDF]

Open Biology, 2012
The transforming growth factor β (TGFβ) signalling pathway plays a central role during embryonic development and in adult tissue homeostasis. It regulates gene transcription through a signalling cascade from cell surface receptors to intracellular SMAD ...
Mazin A. Al-Salihi, Lina Herhaus, Gopal P. Sapkota   +2 more
doaj   +1 more source

Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer. [PDF]

PLoS ONE, 2014
Lung cancer is the second most common cancer and the leading cause of cancer-related deaths. Despite recent advances in the development of targeted therapies, patients with advanced disease remain incurable, mostly because metastatic non-small cell lung ...
Edna Gordian, Jiannong Li, Yuri Pevzner, Melanie Mediavilla-Varela, Kimberly Luddy, Kim Ohaegbulam, Kenyon G Daniel, Eric B Haura, Teresita Muñoz-Antonia   +8 more
doaj   +1 more source

miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-β/Smad Signaling Pathway in Skeletal Muscle Fibrosis

Molecular Therapy: Nucleic Acids, 2018
Fibrosis is common after skeletal muscle injury, undermining tissue regeneration and function. The mechanism underlying skeletal muscle fibrosis remains unveiled.
Yaying Sun, Hui Wang, Yan Li, Shaohua Liu, Jiwu Chen, Hao Ying   +5 more
doaj   +1 more source

Transforming growth factor β1 inhibition protects from noise-induced hearing loss [PDF]

Frontiers in Aging Neuroscience, 2015
Excessive exposure to noise damages the principal cochlear structures leading to hearing impairment. Inflammatory and immune responses are central mechanisms in cochlear defensive response to noise but, if unregulated, they contribute to inner ear damage and hearing loss.
Silvia eMurillo-Cuesta, Silvia eMurillo-Cuesta, Silvia eMurillo-Cuesta, Lourdes eRodríguez-de La Rosa, Lourdes eRodríguez-de La Rosa, Lourdes eRodríguez-de La Rosa, Julio eContreras, Julio eContreras, Julio eContreras, Adelaida M Celaya, Adelaida M Celaya, Guadalupe eCamarero, Guadalupe eCamarero, Guadalupe eCamarero, Teresa eRivera, Teresa eRivera, Teresa eRivera, Isabel eVarela-Nieto, Isabel eVarela-Nieto, Isabel eVarela-Nieto   +19 more
openaire   +5 more sources

Transforming growth factor-β in diabetic nephropathy

The Egyptian Journal of Internal Medicine, 2013
Background Renal failure is a common and serious complication of long-standing diabetes mellitus. Diabetes is the most common cause of end-stage renal failure.
Karima Y. Ahmed, Walaa F. El-Bazz, Hend A. Mohamed, Maha M. Elkeshky   +3 more
doaj   +1 more source

Expression of epidermal growth factor and transforming growth factor α in interfacial membranes retrieved at revision total hip arthroplasty [PDF]

Annals of the Rheumatic Diseases, 2000
The interfacial membrane between bone and implant has been shown to be a key tissue in the process of aseptic loosening of total hip arthroplasty. The cells within the interfacial membrane produce numerous inflammatory mediators which, through complex mechanisms, cause periprosthetic osteolysis and aseptic loosening.
J W, Xu, J, Ma, T F, Li, E, Waris, A, Alberty, S, Santavirta, Y T, Konttinen   +6 more
openaire   +2 more sources

β-catenin and transforming growth factor β have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction

BMC Cell Biology, 2009
Background β-catenin and transforming growth factor β signaling are activated in fibroblasts during wound healing. Both signaling pathways positively regulate fibroblast proliferation during this reparative process, and the effect of transforming growth ...
Slade Laura, Ahn Jessica, Nik Saeid, Poon Raymond, Alman Benjamin A   +4 more
doaj   +1 more source