Results 161 to 170 of about 9,205,124 (201)

Transforming Growth Factor-β1 and Disorders of the Lung

Cell Biochemistry and Biophysics, 2005
The transforming growth factor (TGF) superfamily encompasses about 30 members in mammals. The effect of TGF-beta subfamily members is exerted and regulated via selective pathways of synthesis and signaling that involve activation of latent TGF-beta, specific and high-affinity binding to cell membrane serine/threonine kinase receptors, activation of ...
Blanca, Camoretti-Mercado, Julian, Solway   +1 more
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Transforming growth factor-beta1 and lung allograft fibrosis.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1998
Transforming growth factor beta1 (TGF-beta1) is a potent immunosuppressive cytokine that promotes fibrosis by enhancing the synthesis of extracellular matrix components. The repair process following lung allograft injury is due to rejection or infection replaces lung parenchyma by fibrotic tissue, leading to pulmonary dysfunction. The role of TGF-beta1
El-Gamel, A, Awad, M, Sim, E, Hasleton, P, Egan, J, Yonan, NN A, Deiraniya, A, Hutchinson, I.   +7 more
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Transforming Growth Factor-ß1 and Prostate Cancer

Scandinavian Journal of Urology and Nephrology, 2000
Transforming growth factor-beta1 (TGF-beta1) is an important regulator of the normal and malignant prostate. In the non-malignant prostate, TGF-beta1 stimulates cell differentiation, inhibits epithelial cell proliferation and induces epithelial cell death. TGF-beta1 is secreted into semen and here it is an important immunosuppressive factor.
P, Wikström, A, Bergh, J E, Damber
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Regulation of transforming growth factor beta1 by nitric oxide.

Cancer research, 1999
Many tumor cells or their secreted products suppress the function of tumor-infiltrating macrophages. Tumor cells often produce abundant transforming growth factor beta1 (TGF-beta1), which in addition to other immunosuppressive actions suppresses the inducible isoform of NO synthase.
Y, Vodovotz, L, Chesler, H, Chong, S J, Kim, J T, Simpson, W, DeGraff, G W, Cox, A B, Roberts, D A, Wink, M H, Barcellos-Hoff   +9 more
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[The mechanism of transforming growth factor beta1 in myofibroblast differentiation].

Zhonghua wai ke za zhi [Chinese journal of surgery], 2008
To investigate the mechanism underlying myofibroblast differentiation induced by transforming growth factor (TGF) beta1 in obliterative bronchiolitis following lung transplantation.Heterotopic tracheal transplantation was performed in Smad3 wild-type and knock-out mice to simulate the lung transplantation in human.
Hong-xu, Liu, Si-wen, Wang, Cheng-hai, Zhao, Yang, Liu, Yu, Li, Qi-gang, Zhang, Wei, Cong, Xin-gang, Lan, Shun, Xu, Li-bo, Han, Lin, Zhang   +10 more
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The polymorphism of transforming growth factor-beta1 gene in Japanese patients with systemic sclerosis

British Journal of Dermatology, 2002
Transforming growth factor (TGF)-beta has been shown to be a potent stimulator of collagen production by fibroblasts, and could play a role in the pathogenesis of systemic sclerosis (SSc).To study the possible involvement of TGF-beta1 gene polymorphism in Japanese patients with SSc.Fifty-nine patients with SSc and 110 normal subjects were studied ...
T, Ohtsuka, A, Yamakage, S, Yamazaki
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Adenoviral supply of active transforming growth factor-beta1 (TGF-beta1) did not prevent lethality in transforming growth factor-beta1-knockout embryos.

European cytokine network, 2002
In TGF-beta1-knockout mice, TGF-beta1-null conceptuses die during embryonic development with a penetrance of lethality that depends on the mouse genetic background. Studies have suggested that transplacental passage of maternal TGF-beta1 could account for the rescue of some TGF-beta1-null embryos.
H, Chagraoui, S, Giraudier, W, Vainchenker, F, Wendling   +3 more
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Transforming Growth Factor Beta1 being considered a novel biomarker in knee osteoarthritis

Clinica Chimica Acta, 2017
Associations between Transforming Growth Factor beta-1 (TGF-β1), Platelet-derived growth factor BB (PDGF-BB) and C-terminal telopeptide of type I collagen (CTX-1) with pathogenesis of osteoarthritis (OA) have already been established. Therefore, TGF-β1, PDGF-BB and CTX-1 could be used as the potential biomarkers for the diagnosis of this disease.160 ...
Jianwei, He, Weiwei, Cao, Inayat, Azeem, Qiang, Zhao, Zengwu, Shao   +4 more
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Extracellular matrix is reduced by inhibition of transforming growth factor beta1 in pancreatitis in the rat

Gastroenterology, 1997
Regeneration from cerulein-induced pancreatitis is accompanied by a transient synthesis and deposition of extracellular matrix components in the rat pancreas. The pleiotropic transforming growth factor (TGF)-beta1 has been suggested to regulate extracellular matrix remodeling during regeneration from acute pancreatitis.
A, Menke, H, Yamaguchi, T M, Gress, G, Adler   +3 more
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Mechanism of transforming growth factor-beta1 signaling:.

Kidney international. Supplement, 2001
Mechanism of transforming growth factor-beta1 signaling: Role of the mitogen-activated protein kinase. Transforming growth factor-beta1 (TGF-beta1) regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis.
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