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Transforming Growth Factor Beta1 being considered a novel biomarker in knee osteoarthritis
Clinica Chimica Acta, 2017Associations between Transforming Growth Factor beta-1 (TGF-β1), Platelet-derived growth factor BB (PDGF-BB) and C-terminal telopeptide of type I collagen (CTX-1) with pathogenesis of osteoarthritis (OA) have already been established. Therefore, TGF-β1, PDGF-BB and CTX-1 could be used as the potential biomarkers for the diagnosis of this disease.160 ...
Jianwei, He +4 more
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British Journal of Dermatology, 2002
Transforming growth factor (TGF)-beta has been shown to be a potent stimulator of collagen production by fibroblasts, and could play a role in the pathogenesis of systemic sclerosis (SSc).To study the possible involvement of TGF-beta1 gene polymorphism in Japanese patients with SSc.Fifty-nine patients with SSc and 110 normal subjects were studied ...
T, Ohtsuka, A, Yamakage, S, Yamazaki
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Transforming growth factor (TGF)-beta has been shown to be a potent stimulator of collagen production by fibroblasts, and could play a role in the pathogenesis of systemic sclerosis (SSc).To study the possible involvement of TGF-beta1 gene polymorphism in Japanese patients with SSc.Fifty-nine patients with SSc and 110 normal subjects were studied ...
T, Ohtsuka, A, Yamakage, S, Yamazaki
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Gastroenterology, 1997
Regeneration from cerulein-induced pancreatitis is accompanied by a transient synthesis and deposition of extracellular matrix components in the rat pancreas. The pleiotropic transforming growth factor (TGF)-beta1 has been suggested to regulate extracellular matrix remodeling during regeneration from acute pancreatitis.
A, Menke +3 more
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Regeneration from cerulein-induced pancreatitis is accompanied by a transient synthesis and deposition of extracellular matrix components in the rat pancreas. The pleiotropic transforming growth factor (TGF)-beta1 has been suggested to regulate extracellular matrix remodeling during regeneration from acute pancreatitis.
A, Menke +3 more
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Mechanism of transforming growth factor-beta1 signaling:.
Kidney international. Supplement, 2001Mechanism of transforming growth factor-beta1 signaling: Role of the mitogen-activated protein kinase. Transforming growth factor-beta1 (TGF-beta1) regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis.
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European cytokine network, 2002
In TGF-beta1-knockout mice, TGF-beta1-null conceptuses die during embryonic development with a penetrance of lethality that depends on the mouse genetic background. Studies have suggested that transplacental passage of maternal TGF-beta1 could account for the rescue of some TGF-beta1-null embryos.
H, Chagraoui +3 more
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In TGF-beta1-knockout mice, TGF-beta1-null conceptuses die during embryonic development with a penetrance of lethality that depends on the mouse genetic background. Studies have suggested that transplacental passage of maternal TGF-beta1 could account for the rescue of some TGF-beta1-null embryos.
H, Chagraoui +3 more
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[Gene expression of transforming growth factor-beta1 in osteophyte development].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2010To investigate the gene expression and potential functions of transforming growth factor-beta1 in osteophyte development.A total of 25 specimens were obtained from individuals undergoing total knee arthroplasty due to severe primary osteoarthritis. Tissue samples were embedded in paraffin wax and made into sections.
Jun-wei, Li +6 more
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[Effects of transforming growth factor beta1 on dendritic cells function].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2005To investigate the effects of transforming growth factor beta1 (TGF-beta1) on dendritic cells (DC).Murine bone marrow cells were cultured with different cytokine combinations to develop immature DC (imDC, GM-CSF only) and TGFbeta-DC (GM-CSF + TGF-beta1), and their responses to lipopolysaccharide (LPS) stimulation were observed.
Mao-fang, Lin, Hai-bo, Mou, Hong, Cen
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Transforming growth factor-beta1 expression in human acoustic neuroma.
The American journal of otology, 1999The differing clinical behavior of acoustic neuroma (AN) may be explained by the presence of specific biological features involved in tumorigenesis and growth.Transforming growth factor (TGF) beta1 is known to participate in the regulation of peripheral nerve tumors, modulating cell proliferation and differentiation with mechanisms different from those
M R, Cardillo +4 more
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[Overexpression of transforming growth factor-beta1 in degenerative ligamentum flavum].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2010To investigate the role of transforming growth factor (TGF)-beta1 in degeneration of the ligamentum flavum in the lumbar spine.The degenerative ligamentum flavum was obtained during surgery from 8 patients with lumbar spinal stenosis (mean age 58.6 years), and 8 young patients (mean age 24.2 years) with acute lumbar disc herniation were included as ...
Zhao-ming, Zhong, Jian-ting, Chen
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Serum transforming growth factor-beta1 in asthmatic children
2014Background: Transforming growth factor-beta1 is a multifunctional cytokine which has been linked to the pathogenesis of subepithelial fibrosis and airway wall remodeling in bronchial asthma. Objective: To outline the changes in serum TGF-beta1 in children with bronchial asthma in relation to severity of asthma and different treatment modalities ...
El-Sayed, Zeinab A +3 more
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