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Engineered multifunctional transforming growth factor-β type II receptor ectodomain fusions for oncology applications. [PDF]

open access: yesFront Oncol
Lenferink AEG   +12 more
europepmc   +1 more source

Growth Factors and Malignant Transformation

1993
In the early 1980’s, approaches aimed at identifying the functions of retroviral oncogenes converged with efforts to investigate normal mitogenic signaling by growth factors. A number of retroviral oncogene products were found to be similar to the protein kinase encoded by v-src product1.
S A, Aaronson   +3 more
openaire   +2 more sources

Transforming growth factor‐α

Molecular Reproduction and Development, 1986
Transforming growth factor-α (TGF-α) was first detected in the culture medium of certain retrovirus-transformed cell lines as an activity which binds to the receptor for epidermal growth factor (EGF) and thereby inhibits the binding of EGF. Subsequent examination showed that this factor is made by many other transformed cell lines but not by adult ...
openaire   +1 more source

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