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Transforming growth factors—an overview
Biology of the Cell, 1985Transforming Growth Factors (TGFs) are a sub‐group of a larger family of protein hormones. Two major types of TGF are currently known, alpha‐TGF and beta‐TGF. Biologically their most important property is to act synergistically to induce anchorage‐independent growth of target cells otherwise incapable of such growth. Since this growth parameter is well
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British Medical Bulletin, 1989
Since its discovery as a factor able to induce phenotypic transformation with transforming growth factor alpha, transforming growth factor beta (TGF beta) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types.
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Since its discovery as a factor able to induce phenotypic transformation with transforming growth factor alpha, transforming growth factor beta (TGF beta) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types.
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Epidermal growth factor and transforming growth factor α
British Medical Bulletin, 1989This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth factors alpha (TGF alpha), the biosynthesis and tissue distribution of these molecules and a brief description of the effects of these molecules in culture and animals.
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Epidermal growth factor and transforming growth factor α
Baillière's Clinical Endocrinology and Metabolism, 1991I have attempted here to outline the basic biochemical knowledge that we have now secured on the EGF family of proteins. In the future we will learn much more about the differential role of EGF versus TGF-alpha, about the physiological significance of amphiregulin, the newest member of this family, and about the roles of TGF-alpha and amphiregulin in ...
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Transforming Growth Factor Regulation of Keratinocyte Growth
1993Transforming growth factors (TGF) were originally defined by their ability to induce morphologic transformation in monolayer culture and stimulate soft agar growth of rodent fibroblast cell lines (DeLarco and Todaro 1978; Moses et al. 1981; Roberts et al. 1981). Early studies with TGF indicated that they may play a role in neoplastic transformation and
L, Dagnino +3 more
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Growth regulation by transforming growth factor-β
1993The name transforming growth factor-s (TGF-s) has come to represent a family of highly homologous polypeptides with a wide range of biological activities. The first member of this gene family was identified nearly a decade ago as one of two essential factors, called TGF-α and TGF-s present in the conditioned medium of a murine sarcoma virus-transformed
B A, Arrick, R, Derynck
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Transforming growth factor-? receptors
Cytotechnology, 1989Transforming growth factor beta (TGF-β) binds specifically and with high affinity to several different cell surface proteins. Low M(r) proteins of 50,000 and 80,000 have been termed type I and type II receptors. Intermediate sized binding components of 115,000-140,000 M(r) and a high binding components of approximately 250,000 M(r) in subunit size have
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Epidermal growth factor and transforming growth factor-?? actions on the gut
European Journal of Gastroenterology & Hepatology, 1995Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) are part of a large family of ligands that bind to the epidermal growth factor receptor. While the precise role of these ligands is still unclear, there is little doubt that they play an important role in the development and maintenance of gastrointestinal epithelial ...
R A, Goodlad, N A, Wright
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Transforming growth factor-alpha: an oncodevelopmental growth factor.
Cancer cells (Cold Spring Harbor, N.Y. : 1989), 1990Transforming growth factor-alpha (TGF-alpha) is a 50-amino-acid mitogenic peptide that is structurally and, in some cases, functionally related to members of the epidermal growth factor (EGF) family of peptides. TGF-alpha is initially synthesized as a high-molecular-weight, glycosylated, membrane-associated precursor of approximately 160 amino acids ...
SALOMON DS +3 more
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The transforming growth factors
Trends in Biochemical Sciences, 1985Abstract Transforming growth factors are hormonally active polypeptides that induce phenotypic transformation in normal cells. Two types of transforming growth factors, TGF-α and TGF-s, from both humans and rodents have recently been purified, characterized and cloned. With the identification of cellular receptors for TGF-α and TGF-s we now have more
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