Results 221 to 230 of about 335,996 (268)
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Transforming growth factors and histopathologic interpretation
Journal of the American Academy of Dermatology, 1987Transforming growth factors, a group of small proteins that, under proper circumstances, induce the reversible morphologic transformation of mature cells, are produced by tumor cells and by stimulated differentiated cells. The pseudomalignant conditions that we recognize histologically may, in many instances, be explained by the action of these ...
K S, Stenn, R L, Barnhill, Y, Johnston
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Transformation‐related growth factors and their receptors
The International Journal of Cell Cloning, 1986Cellular transformation may be accomplished in vitro and in vivo through the concerted action of growth factors and oncogenes. This association has demonstrated that malignant growth results from aberrations in growth factor-signal transduction pathways that normally operate to control proliferation. Activation of genes that code for growth factors and/
M D, Bregman, N J, Sipes
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Fibronectin‐associated transforming growth factor
Journal of Cellular Physiology, 1987AbstractWe have studied the ability of fibronectins to induce anchorage‐independent growth of NRK‐49F cells in serum‐free medium. Cells were seeded in soft agar in the presence of various concentrations of plasma fibronectins, and colonies were counted after 10 days.
R A, Fava, D B, McClure
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Growth factors and transformation.
Cancer surveys, 1987There is ample evidence for autocrine action of growth factors in malignant transformation and for recognition of growth factor genes as proto-oncogenes. The design of new expression vectors carrying growth factor genes will permit further study of the specific effects of constitutive growth factor synthesis in cells expressing receptors for the same ...
A B, Roberts, M B, Sporn
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Transforming growth factor alpha.
Cell, 1988In summary, although TGF-alpha was initially found in tumors, a number of later studies, some of them from the author's laboratory, have shown that TGF-alpha should no longer be considered a tumor associated growth factor. Rather, TGF-alpha is a normal physiological ligand for the EGF receptor.
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Growth factors in development, transformation, and tumorigenesis
Cell, 1991Mammalian tissue development and regeneration take place within a milieu of regulatory growth factors. These affect many parameters of cell development, such that survival, proliferation, differentiation, and certain aspects of cell behavior are all influenced by a balance between stimulatory and inhibitory signals.
M, Cross, T M, Dexter
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Epidermal Growth Factor Receptor and Transformation
Surgery Today, 2002The action of transforming growth factor peptides is mediated by distinct membrane receptors, which in turn activate a postreceptor signaling mechanism, eventually resulting in a mitogenic response. Such a signaling pathway may be modified by oncogene expression at the receptor or postreceptor levels, as well as by alterations in the levels of ...
Panagiotis, Boulougouris, James B, Elder
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The epidermal growth factor/transforming growth factor-?? family and their receptors
European Journal of Gastroenterology & Hepatology, 1995Cytokines and growth factors act as intercellular signalling molecules which control cellular functions during development and in response to injury or infection. The epidermal growth factor (EGF) family is an expanding group of structurally related polypeptides that regulate cell proliferation, migration and differentiation, via tyrosine kinase ...
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Autocrine growth factors and tumourigenic transformation
Immunology Today, 1990The development of tumours requires the simultaneous presence of a number of molecular perturbations. It is becoming increasingly clear that autocrine growth factor production, the topic of this review, is one such perturbation. Richard Lang and Antony Burgess summarize recent findings from a variety of in vitro and in vivo animal studies, and ...
R A, Lang, A W, Burgess
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