Results 211 to 220 of about 988,014 (243)

Transforming growth factor-alpha: an oncodevelopmental growth factor.

Cancer cells (Cold Spring Harbor, N.Y. : 1989), 1990
Transforming growth factor-alpha (TGF-alpha) is a 50-amino-acid mitogenic peptide that is structurally and, in some cases, functionally related to members of the epidermal growth factor (EGF) family of peptides. TGF-alpha is initially synthesized as a high-molecular-weight, glycosylated, membrane-associated precursor of approximately 160 amino acids ...
SALOMON DS, KIM N, SAEKI T, CIARDIELLO, Fortunato   +3 more
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Transforming growth factors—an overview

Biology of the Cell, 1985
Transforming Growth Factors (TGFs) are a sub‐group of a larger family of protein hormones. Two major types of TGF are currently known, alpha‐TGF and beta‐TGF. Biologically their most important property is to act synergistically to induce anchorage‐independent growth of target cells otherwise incapable of such growth. Since this growth parameter is well
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Transforming Growth Factor Regulation of Keratinocyte Growth

1993
Transforming growth factors (TGF) were originally defined by their ability to induce morphologic transformation in monolayer culture and stimulate soft agar growth of rodent fibroblast cell lines (DeLarco and Todaro 1978; Moses et al. 1981; Roberts et al. 1981). Early studies with TGF indicated that they may play a role in neoplastic transformation and
L, Dagnino, J A, Pietenpol, E Y, Yang, H L, Moses   +3 more
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Growth regulation by transforming growth factor-β

1993
The name transforming growth factor-s (TGF-s) has come to represent a family of highly homologous polypeptides with a wide range of biological activities. The first member of this gene family was identified nearly a decade ago as one of two essential factors, called TGF-α and TGF-s present in the conditioned medium of a murine sarcoma virus-transformed
B A, Arrick, R, Derynck
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Transforming growth factor-α

Baillière's Clinical Gastroenterology, 1996
Major advances in understanding growth factor biology, especially in epithelial cells, have resulted from work with TGF-alpha over the past decade. It is clear that TGF-alpha is a potent epithelial oncoprotein, but equally important biological activities in normal epithelial homeostasis have been described.
Lisa M. Gangarosa, Peter J. Dempsey, Lars Damstrup, John A. Barnard, Robert J. Coffey   +4 more
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Transforming growth factor‐beta 3.

Cell Biology International, 1995
ABSTRACTTransforming Growth Factor‐Beta (TGF‐β) is the general name for a family of naturally‐occurring polypeptides which have multiple regulatory effects on cell proliferation and differentiation. Over the last decade it has become apparent that TGF‐βs can be produced by most cell types and exert a wide range of effects in a context‐dependent ...
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Transforming growth factor alpha.

Cell, 1988
In summary, although TGF-alpha was initially found in tumors, a number of later studies, some of them from the author's laboratory, have shown that TGF-alpha should no longer be considered a tumor associated growth factor. Rather, TGF-alpha is a normal physiological ligand for the EGF receptor.
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Epidermal Growth Factor and Transforming Growth Factor-α

1988
Since its discovery in 1963 as a polypeptide that accelerated the in vivo maturation of epithelial tissues (Cohen and Elliott, 1963), epidermal growth factor (EGF) has been assumed to be important in regulating epidermal growth, differentiation, and repair.
Lillian B. Nanney, Lloyd E. King
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The transforming growth factors

Trends in Biochemical Sciences, 1985
Abstract Transforming growth factors are hormonally active polypeptides that induce phenotypic transformation in normal cells. Two types of transforming growth factors, TGF-α and TGF-s, from both humans and rodents have recently been purified, characterized and cloned. With the identification of cellular receptors for TGF-α and TGF-s we now have more
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Transforming Growth Factor-β

Clinical Immunology and Immunopathology, 1997
D A, Cox, T, Maurer
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