Results 111 to 120 of about 1,084,742 (347)

FAMILY CASE OF MITRAL VALVE PROLAPSE — IMPACT OF INCREASED LEVEL OF TRANSFORMING  GROWTH FACTOR β

Российский кардиологический журнал, 2018
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M. Yu. Omelchenko, E. G. Malev, L. B. Mitrofanova, L. V. Vasina, E. V. Zemtsovsky, A. O. Nedoshivin   +5 more
doaj   +1 more source

Clinical Relevance of Transforming Growth Factor-β1, Interleukin-6 and Haptoglobin for Prediction of Obesity Complications in Prepubertal Egyptian Children

Open Access Macedonian Journal of Medical Sciences, 2015
BACKGROUND: The rate of obesity is increasing throughout the world. Obesity in adults’ research is characterized by chronic inflammation, associated with type 2 Diabetes and cardiovascular risk. The degree to which these changes occur in childhood obesity is not fully defined.AIM: This study was designed to explore the relation between circulating ...
El-Alameey, Inas R., Fadl, Nevein N., Hameed, Enas R. Abdel, Sherif, Lobna S., Ahmed, Hanaa H.   +4 more
openaire   +3 more sources

Role of Transforming Growth Factor-β in Skeletal Muscle Fibrosis: A Review

International Journal of Molecular Sciences, 2019
Transforming growth factor-beta (TGF-β) isoforms are cytokines involved in a variety of cellular processes, including myofiber repair and regulation of connective tissue formation.
Ahmed Ismaeel, Jeong-Su Kim, J. Kirk, R. S. Smith, W. Bohannon, P. Koutakis   +5 more
semanticscholar   +1 more source

Accumulation, localization, and compartmentation of transforming growth factor beta during endochondral bone development. [PDF]

, 1988
Endochondral bone formation was induced in postnatal rats by implantation of demineralized rat bone matrix. Corresponding control tissue was generated by implanting inactive extracted bone matrix, which did not induce bone formation.
Carrington, JL, Flanders, KC, Reddi, AH, Roberts, AB, Roche, NS   +4 more
core  

Retroviral Expression of Transforming Growth Factor-Alpha Does Not Transform Fibroblasts or Keratinocytes [PDF]

, 1990
Transforming growth factor α (TGFα) is a peptide so named because it helps to impart anchorage-independent growth to normal rat kidney (NRK) cells in vitro and is secreted by many rodent and human tumor cells.
Eric Finzi, Timothy Fleming, Jacalyn H. Pierce, Todaro, Bringman, Derynck, Marquardt, Massague, Carpenter, Todaro, Roberts, Derynck, De Larco, Sporn, Derynck, Lee, Rosenthal, Finzi, Finzi, Kobrin, Coffey, Weissman, Weissman, Mann, Cepko, Graham, Wigler, Gazit, Southern, Rigby, Southern, Adams, Maniatis, Bringman, Coffey, Schreiber, Schultz, Myrdal, Stern, Stern, Rogel, Blam, Gazit, Hendler, Yamamoto, Filmus, King, Wong, Di Marco   +48 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 [PDF]

, 2018
Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is ...
A Clayton, A Desmouliere, A Holmes, A Yabuki, AA Eddy, AA Eddy, AC Sanchez-Lara, BL Aken, C Grupp, C. P. D. Wheeler-Jones, CH Heldin, CL Marino, E Honda, E Van Obberghen-Schilling, F Strutz, F Strutz, F Syeda, GR Grotendorst, H. M. Syme, HP Rodemann, J Ivaska, J Lu, J. Elliott, J. S. Lawson, JL Mumaw, JS Lawson, K Sawashima, KG McCullagh, KJ Kelynack, LC Penning, M Prunotto, M Zeisberg, MA Venkatachalam, MJ Ryan, MK Phanish, ML Sequeira Lopez, P Boor, P Sysa, PC Bartlett, Q Chai, RA Ignotz, S Chakrabarti, S Meran, S Moll, S Neelisetty, SC Chen, SL Lin, SP DiBartola, SW Smith, T Akamatsu, TA Wynn, V Dugina, VS Lebleu, W Bloom, WA Border, X Pan, XM Meng, Y Hosokawa, Y Liu   +58 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer

Cancer Biology & Medicine, 2015
Transforming growth factor-β (TGF-β) is a key factor in cancer development and progression. TGF-β can suppress tumorigenesis by inhibiting cell cycle progression and stimulating apoptosis in early stages of cancer progression. However, TGF-β can modulate
Run-Long Lin, Lu-Jun Zhao
doaj   +1 more source

Hubungan Kadar Transforming Growth Factor-Beta 1 (TGF-β1) Urin dengan Proteinuria pada Anak Sindrom Nefrotik Resisten Steroid

Jurnal Kedokteran Brawijaya, 2013
 Transforming  Growth  Factor-Beta  1  (TGF-β1)  menjadi  perantara  fibrosis  interstisial,  atrofi  tubular,  dan  kerusakan gromelurus ginjal. Proteinuria menunjukkan prognosis yang buruk pada  sindroma nefrotik. Terdapat kecenderungan persisten proteinuria pada sindroma nefrotik resisten steroid.
Prasetya Ismail P, L Enggar Fitri, Krisni Subandijah   +2 more
openaire   +2 more sources