Results 111 to 120 of about 142,802 (274)

Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4⁺ T cells partly via transforming growth factor-β1 [PDF]

, 2016
Tolerogenic dendritic cells (tolDC) are a new immunotherapeutic tool for the treatment of rheumatoid arthritis (RA) and other autoimmune disorders. We have established a method to generate stable tolDC by pharmacological modulation of human monocyte ...
Anderson, A. E., Buck, M., Doran, J. P., Eltherington, O., Harry, R. A., Hilkens, C. M U, Isaacs, J. D., Kirby, J. A., Patterson, A. M., Pratt, A. G., Reynolds, G., Swan, D. J., Wong, O. Y.   +12 more
core   +2 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Age-Dependent Features of Certain Pro- and Anti-Inflammatory Cytokines in the Blood of Patients with Nonviral Liver Cirrhosis

Gastroenterologìa, 2014
Age-dependent features of tumor necrosis factor α, interleukin-4 and transforming growth factor β1 in the blood of patients with liver cirrhosis and their correlation with biochemical markers of liver injury were studied.
V.P. Prysyazhnyuk
doaj   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Metamaterial Antennas Enhance MRI of the Eye and Occipital Brain

Advanced Materials, EarlyView.
A radiofrequency antenna platform comprising planar and bend configurations is developed, incorporating structurally integrated epsilon‐negative metamaterial unit cells to enhance MRI. These antennas enable high‐resolution in vivo human MRI of the eye, orbit, and occipital brain. Comprehensive validation, including simulations, phantom experiments, SAR,
Nandita Saha, Bilguun Nurzed, Mostafa Berangi, Andre Kuehne, Helmar Waiczies, Igor Fabian Tellez Ceja, Xiang Hu, Thomas Gladytz, Lisa Krenz, Dave Huebler, Beate Endemann, Claudia Brockmann, Ebba Beller, Oliver Stachs, Thoralf Niendorf   +14 more
wiley   +1 more source

CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells.

PLoS ONE, 2018
To explore the effects and mechanism of CTEN (COOH-terminus tensin-like molecule) on EMT, cell migration and invasion of Human lung adenocarcinoma cells.
Xiangdong Lu, Juan Gao, Yao Zhang, Tao Zhao, Hongchuan Cai, Tingrong Zhang   +5 more
doaj   +1 more source

尿細管上皮細胞におけるConnective Tissue Growth Factor（CTGF）発現の検討 [PDF]

, 2003
Background/Purpose: Connective tissue growth factor (CTGF) is a member of CCN family which mediates profibrotic effects of transforming growth factor-β1 (TGF-β1), promoting fibroblast proliferation and extracellular matrix (ECM) production. CTGF has been
小林 竜也
core  

Molecular‐Level Insights into Interfacial Adsorption Mechanisms of PFOA on Functional Dolomite Surfaces via AIMD and Spectroscopy

Advanced Materials Interfaces, EarlyView.
Perfluorooctanoic acid (PFOA), ab initio molecular dynamics (AIMD), density functional theory (DFT), Dolomite (DL), metal‐organic frameworks (MOFs), calcined modified dolomite (CDL), zero‐point of charge (PZC), metal‐organic frameworks (MOFs), Fourier transform infrared (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM ...
Yating Yang, Yuhan Li, Zhaohui Li, Hang Wei, Yaqi Wen, Po‐Hsiang Chang, Christopher Rensing, Ahmed I. Osman, Baoyu Kong   +8 more
wiley   +1 more source

Proteolytic and Non-proteolytic Activation of Keratinocyte-Derived Latent TGF-β1 Induces Fibroblast Differentiation in a Wound-Healing Model Using Rat Skin

Journal of Pharmacological Sciences, 2014
Transforming growth factor-β1 (TGF-β1) reportedly causes the differentiation of fibroblasts to myofibroblasts during wound healing. We investigated the mechanism underlying the activation of latent TGF-β1 released by keratinocytes in efforts to identify ...
Shozaburo Hata, Kazuhiko Okamura, Mitsutoki Hatta, Hiroyuki Ishikawa, Jun Yamazaki   +4 more
doaj   +1 more source