Results 101 to 110 of about 41,942 (251)

Arrest of endotoxin-induced hypotension by transforming growth factor beta1. [PDF]

Proceedings of the National Academy of Sciences, 1996
Septic shock is a cytokine-mediated process typically caused by a severe underlying infection. Toxins generated by the infecting organism trigger a cascade of events leading to hypotension, to multiple organ system failure, and frequently to death. Beyond supportive care, no effective therapy is available for the treatment of septic shock. Nitric oxide
M A, Perrella, C M, Hsieh, W S, Lee, S, Shieh, J C, Tsai, C, Patterson, C J, Lowenstein, N C, Long, E, Haber, S, Shore, M E, Lee   +10 more
openaire   +2 more sources

CD44‐Targeted Antioxidant Nanosheets Attenuate Pulmonary Fibrosis by Inhibiting the ROS‐STAT1‐CXCL10 Axis

Small Structures, Volume 7, Issue 3, March 2026.
Here, we report a CD44‐targeted antioxidant nanoplatform based on chondroitin sulfate‐functionalized MoS2 nanosheets (CLM NSs). In a murine pulmonary fibrosis model, CLM NSs achieve lesion‐specific accumulation, scavenge reactive oxygen/nitrogen species, and inhibit fibroblast activation and epithelial‐mesenchymal transition by blocking the ROS‐STAT1 ...
Wencheng Gong, Yu Huang, Ting Wang, Hanchao Zhou, Yue Zhang, Chen Zhang, Ke Wang, Lijuan Liu   +7 more
wiley   +1 more source

Potential targets of transforming growth factor-beta1 during inhibition of oocyte maturation in zebrafish

Reproductive Biology and Endocrinology, 2005
Background TGF-beta is a multifunctional growth factor involved in regulating a variety of cellular activities. Unlike mammals, the function of TGF-beta in the reproduction of lower vertebrates, such as fish, is not clear.
Clelland Eric, Kohli Gurneet, Peng Chun
doaj   +1 more source

Angiotensin II induces hypertrophy of human airway smooth muscle cells: expression of transcription factors and transforming growth factor-beta1 [PDF]

, 1998
Increased smooth muscle mass due to hyperplasia and hypertrophy of airway smooth muscle (ASM) cells is a common feature in asthma. Angiotensin II (Ang II), a potent vasoconstrictor and mitogen for a wide variety of cells,
Jongste, J.C. (Johan) de, McKay, S. (Sue), Saxena, P.R. (Pramod Ranjan), Sharma, H.S. (Hari)   +3 more
core  

Prognostic value of fetal growth and prenatal functional echocardiography in tetralogy of FALLOT

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 3, Page 479-491, March 2026.
First demonstration that fetal growth and pulmonary peak velocity at third trimester are independent predictors of postnatal outcome in Tetralogy of Fallot. This may enhance the accuracy of prenatal counseling and facilitate more individualized planning for delivery and neonatal care. Abstract Introduction Tetralogy of Fallot (ToF) shows variability in
Laura Nogué, Mar Bennasar, Laura Guirado, Felix Zölner, Justus Reitz, Roland Axt‐Fliedner, María C. Escobar‐Díaz, Josep Maria Martínez, Eduard Gratacós, Fàtima Crispi, Olga Gómez, for the BCNatal and Gießen and Marburg University investigators, Míriam Pérez‐Cruz, Narcís Masoller, Franziska Holland, Mireia Caballero, Marta Guilleumes, Sergi Cesar   +17 more
wiley   +1 more source

Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. [PDF]

PLoS ONE, 2008
BACKGROUND: Heterogeneous and uncontrolled differentiation of human embryonic stem cells (hESCs) in embryoid bodies (EBs) limits the potential use of hESCs for cell-based therapies.
Nathaniel S Hwang, Shyni Varghese, Jennifer Elisseeff   +2 more
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis [PDF]

, 2016
Liver cirrhosis is the outcome of chronic liver injury. The current study aimed to investigate the therapeutic effect of undifferentiated mesenchymal stem cells versus in vitro partially differentiated mesenchymal stem cells on liver cirrhosis and ...
Amin, Shaimaa Nasr, Elberry, Dalia Azmy, Esmail, Reham Shehab El Nemr, Gamal, Maha Mohamed, Rashed, Laila Ahmed   +4 more
core   +1 more source

Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu, Zhi‐Ping Jin, Shu‐Qiang Weng, Ji‐Min Zhu, Ling Dong   +4 more
wiley   +1 more source

Decreased plasma gelsolin in the COVID-19-related acute respiratory distress syndrome

Türk Biyokimya Dergisi
The aim of this study was to evaluate the potential roles of plasma gelsolin (pGSN), transforming growth factor-beta1 (TGF-β1), and lysophosphatidic acid (LPA) as profibrotic and immune modulatory markers in patients with acute respiratory distress ...
Gunturk Inayet, Seydel Gonul Seyda, Yazici Cevat, Topaloglu Ulas Serkan, Eren Esma, Yuksel Recep Civan   +5 more
doaj   +1 more source