Results 81 to 90 of about 41,942 (251)

T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases

open access: yesImmunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter   +3 more
wiley   +1 more source

Transforming Growth Factor-β1—Modulated Cerebral Gene Expression [PDF]

open access: yesJournal of Cerebral Blood Flow & Metabolism, 2002
Transforming growth factor-β1 (TGF-β1) plays a central role in the response of the brain to different types of injury. Increased TGF-β1 has been found in the central nervous system of patients with acute or chronic disorders such as stroke or Alzheimer disease.
Sylvain, Lesné   +9 more
openaire   +2 more sources

Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]

open access: yes, 2007
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland   +16 more
core   +2 more sources

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

open access: yesAdvanced Science, Volume 13, Issue 24, 27 April 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu   +4 more
wiley   +1 more source

MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine. [PDF]

open access: yes, 2017
The high degree of conservation in microRNA from Caenorhabditiselegans to humans has enabled relatively rapid implementation of findings in model systems to the clinic.
Agarwal, Priyanka   +2 more
core   +1 more source

Mild cognitive impairment‐to‐Alzheimer's dementia progression risk: the contribution of the Interceptor project

open access: yesAlzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract BACKGROUND Mild cognitive impairment (MCI) is an intermediate stage between normal and pathological brain aging, with 30% to 50% progressing to dementia within 3 to 5 years. Early identification of individuals at high risk of progression is crucial for public health strategies.
Flavia L. Lombardo   +17 more
wiley   +1 more source

Strong genetic differentiation but limited niche partitioning in a sympatric species pair separated by an allochronic reproductive barrier

open access: yesSystematic Entomology, Volume 51, Issue 2, April‐June 2026.
Sympatric sister species demonstrate substantial geographic and host overlap, with ecological analyses only finding subtle microecological variation in habitat use. Molecular analyses reveal clear genetic differentiation with no evidence of hybridization, suggesting strong reproductive isolation between species. Differences in time‐of‐day mating appear
Mitchell Irvine   +10 more
wiley   +1 more source

Evaluation of Transforming Growth Factor Beta-1 Gene 869T/C Polymorphism with Hypertension: A Meta-Analysis

open access: yesInternational Journal of Hypertension, 2011
Association between transforming growth factor beta-1 gene (TGFB1) 869T/C polymorphism and hypertension has been widely evaluated, yet with conflicting results.
Wenquan Niu
doaj   +1 more source

Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis [PDF]

open access: yes, 2005
Transforming growth factor-beta (TGF-beta) plays a crucial role in the pathogenesis of skin fibrotic diseases. Systemic TGF-beta inhibitors effectively inhibit fibrosis in different animal models; however, systemic inhibition of TGF-beta raises important
Borras-Cuesta, F. (Francisco)   +8 more
core  

New targets for resolution of airway remodeling in obstructive lung diseases. [PDF]

open access: yes, 2018
Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).
Deshpande, Deepak A.   +2 more
core   +2 more sources

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