Results 81 to 90 of about 41,942 (251)
T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases
ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter +3 more
wiley +1 more source
Transforming Growth Factor-β1—Modulated Cerebral Gene Expression [PDF]
Transforming growth factor-β1 (TGF-β1) plays a central role in the response of the brain to different types of injury. Increased TGF-β1 has been found in the central nervous system of patients with acute or chronic disorders such as stroke or Alzheimer disease.
Sylvain, Lesné +9 more
openaire +2 more sources
Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland +16 more
core +2 more sources
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu +4 more
wiley +1 more source
MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine. [PDF]
The high degree of conservation in microRNA from Caenorhabditiselegans to humans has enabled relatively rapid implementation of findings in model systems to the clinic.
Agarwal, Priyanka +2 more
core +1 more source
Abstract BACKGROUND Mild cognitive impairment (MCI) is an intermediate stage between normal and pathological brain aging, with 30% to 50% progressing to dementia within 3 to 5 years. Early identification of individuals at high risk of progression is crucial for public health strategies.
Flavia L. Lombardo +17 more
wiley +1 more source
Sympatric sister species demonstrate substantial geographic and host overlap, with ecological analyses only finding subtle microecological variation in habitat use. Molecular analyses reveal clear genetic differentiation with no evidence of hybridization, suggesting strong reproductive isolation between species. Differences in time‐of‐day mating appear
Mitchell Irvine +10 more
wiley +1 more source
Association between transforming growth factor beta-1 gene (TGFB1) 869T/C polymorphism and hypertension has been widely evaluated, yet with conflicting results.
Wenquan Niu
doaj +1 more source
Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis [PDF]
Transforming growth factor-beta (TGF-beta) plays a crucial role in the pathogenesis of skin fibrotic diseases. Systemic TGF-beta inhibitors effectively inhibit fibrosis in different animal models; however, systemic inhibition of TGF-beta raises important
Borras-Cuesta, F. (Francisco) +8 more
core
New targets for resolution of airway remodeling in obstructive lung diseases. [PDF]
Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).
Deshpande, Deepak A. +2 more
core +2 more sources

