Results 151 to 160 of about 9,295,419 (200)
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Suppression of Transforming Growth Factor-beta1 Expression in Keloids After Cryosurgery
Cryobiology, 2017The biological mechanism underlying cryosurgical treatment of keloids remains unclear. Transforming growth factor-beta1 (TGF-β1) has been implicated in the pathogenesis of keloids and was reported to be the target of several therapeutic modalities. However, the effect of cryosurgery on its expression in keloid tissue has not been yet investigated.
Rania Makboul, Abeer Refaiy, Sara M Awad
exaly +3 more sources
Transforming growth factor-beta1 and regulators of apoptosis.
Annals of the New York Academy of Sciences, 2009Growth inhibitory function of transforming growth factor-beta1 (TGF-beta1) is abolished in colorectal cancer cells as a consequence of mutations of various downstream signaling agents, such as p53, which fail to respond to TGF-beta1 stimulation. TGF-beta1 could also suppress T-cell-mediated anticancer immunity.
Stanislaw, Sulkowski +3 more
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The role of transforming growth factor β1 in the vascular system
Cardiovascular Pathology, 2005The transforming growth factor beta (TGFbeta) family of cytokines exert pleiotropic effects upon a wide variety of cell types. TGFbeta1 has been demonstrated to be of fundamental importance in the development, physiology and pathology of the vascular system.
Ghosh, J +6 more
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Transforming Growth Factor β1: Implications in Adrenocortical Tumorigenesis
Endocrine Research, 2000TGFbeta1, a multifunctional growth modulator, inhibits the proliferation of epithelial cells. TGFbeta1 signaling is dependent on the heterodimerization of the TGFbeta1 receptor II (TGFbeta1RII) with the TGFbeta1 receptor I (TGFbeta1RI). The cytoplasmic proteins Smads are the mediators of the TGFbeta1 signal.
ARNALDI G. +4 more
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Transforming Growth Factor-β1 and Disorders of the Lung
Cell Biochemistry and Biophysics, 2005The transforming growth factor (TGF) superfamily encompasses about 30 members in mammals. The effect of TGF-beta subfamily members is exerted and regulated via selective pathways of synthesis and signaling that involve activation of latent TGF-beta, specific and high-affinity binding to cell membrane serine/threonine kinase receptors, activation of ...
Blanca, Camoretti-Mercado +1 more
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Transforming Growth Factor-ß1 and Prostate Cancer
Scandinavian Journal of Urology and Nephrology, 2000Transforming growth factor-beta1 (TGF-beta1) is an important regulator of the normal and malignant prostate. In the non-malignant prostate, TGF-beta1 stimulates cell differentiation, inhibits epithelial cell proliferation and induces epithelial cell death. TGF-beta1 is secreted into semen and here it is an important immunosuppressive factor.
P, Wikström, A, Bergh, J E, Damber
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Mandibular Reconstruction With Transforming Growth Factor‐β1
The Laryngoscope, 1998AbstractHypothesis: Transforming growth factor‐β1 (TGF‐β1) plus demineralized bone matrix (DBM) will reconstruct a critical mandibular defect devoid of periosteum in a canine model.Study Design: Randomized, blinded, placebo‐controlled, prospective animal pilot study.Methods: Canine critical mandibular defects devoid of periosteum were reconstructed ...
D A, Sherris +3 more
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Urology, 2006
To study the potential role of pelviureteral junction obstruction (PUJO) in causing progressive renal damage in children through the renal expression of epidermal growth factor (EGF) and transforming growth factor-beta1 (TGF-beta1).The expression of EGF and TGF-beta1 was evaluated in the renal tissues of 25 children with congenital hydronephrosis by ...
Yi, Yang +3 more
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To study the potential role of pelviureteral junction obstruction (PUJO) in causing progressive renal damage in children through the renal expression of epidermal growth factor (EGF) and transforming growth factor-beta1 (TGF-beta1).The expression of EGF and TGF-beta1 was evaluated in the renal tissues of 25 children with congenital hydronephrosis by ...
Yi, Yang +3 more
openaire +2 more sources
European cytokine network, 2002
In TGF-beta1-knockout mice, TGF-beta1-null conceptuses die during embryonic development with a penetrance of lethality that depends on the mouse genetic background. Studies have suggested that transplacental passage of maternal TGF-beta1 could account for the rescue of some TGF-beta1-null embryos.
H, Chagraoui +3 more
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In TGF-beta1-knockout mice, TGF-beta1-null conceptuses die during embryonic development with a penetrance of lethality that depends on the mouse genetic background. Studies have suggested that transplacental passage of maternal TGF-beta1 could account for the rescue of some TGF-beta1-null embryos.
H, Chagraoui +3 more
openaire +1 more source
Transforming growth factor-beta1 inhibits steroidogenesis in human trophoblast cells
Molecular Human Reproduction, 2002Transforming growth factor-beta (TGF-beta) is an important regulator of placental development and function. In this study, we have investigated the effect of TGF-beta1 on steroidogenesis, as well as its sites of action in the steroidogenic pathway by using a choriocarcinoma cell line, JEG-3, and a normal trophoblast cell line (NPC).
Shuang, Luo +3 more
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