Results 31 to 40 of about 13,909 (174)

Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling

Neurobiology of Pain, 2022
Low-dose interleukin-2 (LD-IL-2) treatment has been shown to effectively reverse chronic migraine-related behaviors and the sensitization of trigeminal ganglion (TG) neurons through expansion and activation of peripheral regulatory T cells (Tregs) in ...
Zhaohua Guo, Jintao Zhang, Xuemei Liu, Jacqueline Unsinger, Richard S Hotchkiss, Yu-Qing Cao   +5 more
doaj   +1 more source

Thirty Years of Autologous Platelet Concentrates: From Platelet‐Rich Plasma to Platelet‐Rich Fibrin

Journal of Periodontal Research, EarlyView.
This review highlights the 30 years of evolution of APCs, with a focus on their clinical applications and recent technological advancements. ABSTRACT Nearly three decades have now passed since autologous platelet concentrates (APCs) were introduced into clinical practice.
Richard J. Miron, Nathan E. Estrin, Paras Ahmad, Nima Farshidfar, Masako Fujioka‐Kobayashi, Yufeng Zhang, Mario Romandini, Reinhard Gruber   +7 more
wiley   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Transforming Growth Factor-β1 Is a Negative Modulator of Adult Neurogenesis [PDF]

Journal of Neuropathology and Experimental Neurology, 2006
Transforming growth factor (TGF)-beta1 has multiple functions in the adult central nervous system (CNS). It modulates inflammatory responses in the CNS and controls proliferation of microglia and astrocytes. In the diseased brain, TGF-beta1 expression is upregulated and, depending on the cellular context, its activity can be beneficial or detrimental ...
Frank-Peter, Wachs, Beate, Winner, Sebastien, Couillard-Despres, Thorsten, Schiller, Robert, Aigner, Jürgen, Winkler, Ulrich, Bogdahn, Ludwig, Aigner   +7 more
openaire   +2 more sources

Irisin Regulates the Functions of Hepatic Stellate Cells [PDF]

Endocrinology and Metabolism, 2020
Background Hepatic stellate cells (HSCs) are known to play a fundamental role in the progression of liver fibrosis. Once HSCs are activated, they are involved in proliferation, migration, and contractility which are characteristics of liver fibrogenesis.
Hanh Nguyen Dong, So Young Park, Cong Thuc Le, Dae-Hee Choi, Eun-Hee Cho   +4 more
doaj   +1 more source

Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment

Exploration, Volume 6, Issue 3, June 2026.
This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yisheng Chen, Zhijie Zhao, Changli Wang, Xiaomin Zhang   +11 more
wiley   +1 more source

Transforming growth factor beta-1 in patients with hypertension who had COVID-19

Medičnì Perspektivi
Post-covid syndrome is a multisystem disease. The totality of disorders of organs and systems, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes significant damage to human health for a long time, especially if the patient ...
O.V. Kuryata , O.S. Mytrokhina, O.I. Stadnyk   +2 more
doaj   +1 more source

IGF-I production by adult rat hepatocytes is stimulated by transforming growth factor-alpha and transforming growth factor-beta1 [PDF]

European Journal of Endocrinology, 1999
Previously, we have observed that epidermal growth factor (EGF), a potent mitogen for cultured hepatocytes, stimulates the production of IGF-I and IGF-binding proteins (IGFBPs) by cultured hepatocytes from adult rats. This study was undertaken to investigate the possibility that other growth factors of hepatic origin could specifically be involved in ...
VOCI, ADRIANA, ARVIGO, MARICA, MASSAJOLI M., GARRONE S., BOTTAZZI C., DEMORI, ILARIA, GALLO, GABRIELLA   +6 more
openaire   +3 more sources

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Tumor Anti‐Angiogenesis Therapy and Its Influence on Immune Cell Function in the Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Vascular normalization, one promising anti‐angiogenic strategy, has the potential to enhance vascular perfusion and elevate the infiltration of immune cells into tumors by rectifying aberrant tumor blood vessels. This results in the enhancement of immunotherapy.
Yu Tang, Yuyan Ding, LiPing Wang, Yujiao Yang, Youwei Han, Peng Zhou, Huiheng Qu, Kaiyuan Deng, Jiazeng Xia   +8 more
wiley   +1 more source