Results 1 to 10 of about 1,928 (119)

Obesity and endocrine-disrupting chemicals

Endocrine Connections, 2021
Obesity is now a worldwide pandemic. The usual explanation given for the prevalence of obesity is that it results from consumption of a calorie dense diet coupled with physical inactivity.
Angelica Amorim Amato, Hailey Brit Wheeler, Bruce Blumberg   +2 more
doaj   +1 more source

Modeling early germline immunization after horizontal transfer of transposable elements reveals internal piRNA cluster heterogeneity

BMC Biology, 2023
Background A fraction of all genomes is composed of transposable elements (TEs) whose mobility needs to be carefully controlled. In gonads, TE activity is repressed by PIWI-interacting RNAs (piRNAs), a class of small RNAs synthesized by heterochromatic ...
Amna Asif-Laidin, Karine Casier, Zoheir Ziriat, Antoine Boivin, Elise Viodé, Valérie Delmarre, Stéphane Ronsseray, Clément Carré, Laure Teysset   +8 more
doaj   +1 more source

Transgenerational Effects of Prenatal Endocrine Disruption on Reproductive and Sociosexual Behaviors in Sprague Dawley Male and Female Rats

Toxics, 2022
Endocrine-disrupting chemicals (EDCs) lead to endocrine and neurobehavioral changes, particularly due to developmental exposures during gestation and early life.
Bailey A. Kermath, Lindsay M. Thompson, Justin R. Jefferson, Mary H. B. Ward, Andrea C. Gore   +4 more
doaj   +1 more source

Association of Prenatal Famine Exposure With Inflammatory Markers and Its Impact on Adulthood Liver Function Across Consecutive Generations

Frontiers in Nutrition, 2022
Although there has been increasing recognition that famine exposure in the fetal stage damages liver function in adulthood, this deteriorated effect could be extended to the next generation remains vague.
Shiwei Yan, Jingqi Ruan, Yu Wang, Jiaxu Xu, Changhao Sun, Yucun Niu   +5 more
doaj   +1 more source

Functional Somatic Symptoms and Emotion Regulation in Children and Adolescents

Clinical Psychology in Europe, 2022
[Background] Functional Somatic Symptoms (FSS; i.e. symptoms without sufficient organic explanation) often begin in childhood and adolescence and are common to this developmental period.
Stefanie M. Jungmann, Louisa Wagner, Marlene Klein, Aleksandra Kaurin   +3 more
doaj   +1 more source

Transgenerational mutation by radiation [PDF]

Nature, 2000
Parental exposure to ionizing radiation increases the frequency of germline mutations detectable in the next generation1. Parental exposure can also increase the rate of mutation in somatic cells2,3 and confer a predisposition to cancer4,5,6 in offspring, suggesting that there could be an indirect effect of radiation on somatic genome stability that is
Dubrova, YE, Plumb, M, Gutierrez, B, Boulton, E, Jeffreys, AJ   +4 more
openaire   +3 more sources

Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

eLife, 2021
Despite reports of parental exposure to stress promoting physiological adaptations in progeny in diverse organisms, there remains considerable debate over the significance and evolutionary conservation of such multigenerational effects.
Nicholas O Burton, Alexandra Willis, Kinsey Fisher, Fabian Braukmann, Jonathan Price, Lewis Stevens, L Ryan Baugh, Aaron Reinke, Eric A Miska   +8 more
doaj   +1 more source

Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans

eLife, 2020
A rapidly growing body of literature in several organisms suggests that environmentally-induced adaptive changes in phenotype can be transmitted across multiple generations.
L Ryan Baugh, Troy Day
doaj   +1 more source

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

Toxics, 2022
Per- and polyfluoroalkyl substances (PFASs) are ubiquitous in the environment and are tied to myriad health effects. Despite the phasing out of the manufacturing of two types of PFASs (perfluorosulfonic acid (PFOS) and perfluorooctanoic acid (PFOA ...
Alex Haimbaugh, Chia-Chen Wu, Camille Akemann, Danielle N. Meyer, Mackenzie Connell, Mohammad Abdi, Aicha Khalaf, Destiny Johnson, Tracie R. Baker   +8 more
doaj   +1 more source

Development of a novel Guinea Pig model producing transgenerational endothelial transcriptional changes driven by maternal food restriction and a second metabolic insult of high fat diet

Frontiers in Physiology, 2023
Developmental programming of chronic adverse cardiovascular health outcomes has been studied both using numerous human populations and an array of animal models.
Hillary H. Le, Matthew W. Hagen, Samantha Louey, Samantha Louey, Hagai Tavori, Kent L. Thornburg, Kent L. Thornburg, Kent L. Thornburg, George D. Giraud, George D. Giraud, George D. Giraud, George D. Giraud, Monica T. Hinds, Monica T. Hinds, Anthony P. Barnes   +14 more
doaj   +1 more source