Results 11 to 20 of about 17,268 (246)

Transgenerational mutation by radiation [PDF]

Nature, 2000
Parental exposure to ionizing radiation increases the frequency of germline mutations detectable in the next generation1. Parental exposure can also increase the rate of mutation in somatic cells2,3 and confer a predisposition to cancer4,5,6 in offspring, suggesting that there could be an indirect effect of radiation on somatic genome stability that is
Dubrova, YE, Plumb, M, Gutierrez, B, Boulton, E, Jeffreys, AJ   +4 more
openaire   +3 more sources

Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

eLife, 2021
Despite reports of parental exposure to stress promoting physiological adaptations in progeny in diverse organisms, there remains considerable debate over the significance and evolutionary conservation of such multigenerational effects.
Nicholas O Burton, Alexandra Willis, Kinsey Fisher, Fabian Braukmann, Jonathan Price, Lewis Stevens, L Ryan Baugh, Aaron Reinke, Eric A Miska   +8 more
doaj   +1 more source

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio)

Toxics, 2022
Per- and polyfluoroalkyl substances (PFASs) are ubiquitous in the environment and are tied to myriad health effects. Despite the phasing out of the manufacturing of two types of PFASs (perfluorosulfonic acid (PFOS) and perfluorooctanoic acid (PFOA ...
Alex Haimbaugh, Chia-Chen Wu, Camille Akemann, Danielle N. Meyer, Mackenzie Connell, Mohammad Abdi, Aicha Khalaf, Destiny Johnson, Tracie R. Baker   +8 more
doaj   +1 more source

Development of a novel Guinea Pig model producing transgenerational endothelial transcriptional changes driven by maternal food restriction and a second metabolic insult of high fat diet

Frontiers in Physiology, 2023
Developmental programming of chronic adverse cardiovascular health outcomes has been studied both using numerous human populations and an array of animal models.
Hillary H. Le, Matthew W. Hagen, Samantha Louey, Samantha Louey, Hagai Tavori, Kent L. Thornburg, Kent L. Thornburg, Kent L. Thornburg, George D. Giraud, George D. Giraud, George D. Giraud, George D. Giraud, Monica T. Hinds, Monica T. Hinds, Anthony P. Barnes   +14 more
doaj   +1 more source

Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans

eLife, 2020
A rapidly growing body of literature in several organisms suggests that environmentally-induced adaptive changes in phenotype can be transmitted across multiple generations.
L Ryan Baugh, Troy Day
doaj   +1 more source

Maternal Chronic Ethanol Exposure Decreases Stress Responses in Zebrafish Offspring

Biomolecules, 2022
In humans, prenatal alcohol exposure can cause serious health issues in children, known collectively as Foetal Alcohol Spectrum Disorders (FASD). Despite the high prevalence of FASD and a lack of effective treatments, the underlying mechanisms causing ...
Juliet E. Kitson, James Ord, Penelope J. Watt   +2 more
doaj   +1 more source

Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs

Cells, 2019
Environmentally-induced transgenerational epigenetic inheritance is an emerging field. The understanding of associated epigenetic mechanisms is currently in progress with open questions still remaining.
Karine Casier, Antoine Boivin, Clément Carré, Laure Teysset   +3 more
doaj   +1 more source

Epigenetics and Methylmercury-Induced Neurotoxicity, Evidence from Experimental Studies

Toxics, 2023
MeHg is an environmental neurotoxin that can adversely affect the development of the nervous system. The molecular integrity of chromatin in the nucleus is an important target of MeHg. Low levels of MeHg trigger epigenetic mechanisms that may be involved
Tao Ke, Alexey A. Tinkov, Anatoly V. Skalny, Abel Santamaria, Joao B. T. Rocha, Aaron B. Bowman, Wen Chen, Michael Aschner   +7 more
doaj   +1 more source

Transgenerational epigenetic inheritance [PDF]

Current Biology, 2003
What is it? If you thought all heritable traits are written in the DNA sequence, think again! We have come to realize that, at some alleles, the epigenetic state of the DNA can also be inherited. This is indicated by analysis of alleles where the establishment of the epigenetic state is stochastic.
Rakyan, Vardhman, Whitelaw, Emma
openaire   +2 more sources

Transgenerational developmental programming [PDF]

Human Reproduction Update, 2013
The concept of developmental programming suggests that the early life environment influences offspring characteristics in later life, including the propensity to develop diseases such as the metabolic syndrome. There is now growing evidence that the effects of developmental programming may also manifest in further generations without further suboptimal
Catherine E, Aiken, Susan E, Ozanne
openaire   +2 more sources