Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans
eLife, 2020 A rapidly growing body of literature in several organisms suggests that environmentally-induced adaptive changes in phenotype can be transmitted across multiple generations.
L Ryan Baugh, Troy Day
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Maternal Chronic Ethanol Exposure Decreases Stress Responses in Zebrafish Offspring
Biomolecules, 2022 In humans, prenatal alcohol exposure can cause serious health issues in children, known collectively as Foetal Alcohol Spectrum Disorders (FASD). Despite the high prevalence of FASD and a lack of effective treatments, the underlying mechanisms causing ...
Juliet E. Kitson +2 more
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Transgenerational developmental programming [PDF]
Human Reproduction Update, 2013 The concept of developmental programming suggests that the early life environment influences offspring characteristics in later life, including the propensity to develop diseases such as the metabolic syndrome. There is now growing evidence that the effects of developmental programming may also manifest in further generations without further suboptimal
Catherine E, Aiken, Susan E, Ozanne
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Epigenetics and Methylmercury-Induced Neurotoxicity, Evidence from Experimental Studies
Toxics, 2023 MeHg is an environmental neurotoxin that can adversely affect the development of the nervous system. The molecular integrity of chromatin in the nucleus is an important target of MeHg. Low levels of MeHg trigger epigenetic mechanisms that may be involved
Tao Ke +7 more
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Transgenerational Genetic Effects [PDF]
Epigenomics, 2010 Since Mendel, studies of phenotypic variation and disease risk have emphasized associations between genotype and phenotype among affected individuals in families and populations. Although this paradigm has led to important insights into the molecular basis for many traits and diseases, most of the genetic variants that control the inheritance of these ...
Vicki R, Nelson, Joseph H, Nadeau
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Cells, 2019 Environmentally-induced transgenerational epigenetic inheritance is an emerging field. The understanding of associated epigenetic mechanisms is currently in progress with open questions still remaining.
Karine Casier +3 more
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Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans. [PDF]
, 2015 UNLABELLED: Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and ...
Ashe, Alyson +4 more
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Paternal early experiences influence infant development through non-social mechanisms in Rhesus Macaques. [PDF]
, 2015 BackgroundEarly experiences influence the developing organism, with lifelong and potentially adaptive consequences. It has recently become clear that the effects of early experiences are not limited to the exposed generation, but can influence ...
Capitanio, John P, Kinnally, Erin L
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Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems [PDF]
, 2018 Freshwater ecosystems are amongst the most threatened ecosystems on Earth. Currently, climate change is one of the most important drivers of freshwater transformation and its effects include changes in the composition, biodiversity and functioning of ...
Allen +166 more
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The Effects of Different Diets and Transgenerational Stress on Acyrthosiphon pisum Development. [PDF]
, 2019 Despite the fact that sap-feeding hemipterans are major agricultural pests, little is known about the pea aphid's (Acyrthosiphon pisum) nymphal development, compared to other insect models. Given our limited understanding of A.
Hansen, Allison K, Pers, Daniel
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