Results 211 to 220 of about 118,253 (302)

Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations. [PDF]

J Immunother Cancer
Rommel PC, Engel NW, Malachowski JK, Shukla D, Hodson IR, Gonzales D, van der Loo JCM, Young RM, Riley JL, Levine BL, June CH.   +10 more
europepmc   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Ribozyme-Enabled Tissue Specificity (RETS): A System for Precise Gene Expression without Specialized Promoters. [PDF]

ACS Synth Biol
Combest MM, Conlin J, Van De Mark V, Boisen M, Colwell H, Khakhar A.   +5 more
europepmc   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Callus and endosperm green fluorescence reporter-assisted selection system in maize CRISPR/Cas9 gene editing. [PDF]

BMC Plant Biol
Ge L, Li W, Dou Y, Ma Y, Sun M, Chen X, Feng X, Li Y, Yu Q.   +8 more
europepmc   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Both isoforms of Drosophila ApoLpp (ApoB) cross the blood-brain barrier in adults. [PDF]

Genetics
Stinchfield MJ, Gadagkar SR, O'Connor MB, Newfeld SJ.   +3 more
europepmc   +1 more source

Engineering compact Physalis peruviana (goldenberry) to promote its potential as a global crop

PLANTS, PEOPLE, PLANET, EarlyView.
Goldenberry (Physalis peruviana) produces sweet, nutritionally rich berries, yet like many minor crops, is cultivated in limited geographical regions and has not been a focus of breeding programs for trait enhancement. Leveraging knowledge of plant architecture‐related traits from related species, we used CRISPR/Cas9‐mediated gene editing to generate a
Miguel Santo Domingo, Blaine Fitzgerald, Gina M. Robitaille, Srividya Ramakrishnan, Kerry Swartwood, Nicholas G. Karavolias, Michael C. Schatz, Joyce Van Eck, Zachary B. Lippman   +8 more
wiley   +1 more source

Highly efficient gene editing via targeted Cas9 insertion into chicken housekeeping gene. [PDF]

Poult Sci
Jung KM, Klein R, Mony SI, Chen PR, Lee K, Lee HJ.   +5 more
europepmc   +1 more source

Transport engineering as a strategy to realize rapeseed's potential as a protein‐rich food

Pest Management Science, EarlyView.
The heavily pesticide‐dependent rapeseed is an under‐utilized protein source for food owing to anti‐nutritional glucosinolates. Transport engineering technology may reduce glucosinolates in seeds while increasing defense in vegetative parts. Abstract Rapeseed is the world's second‐largest oilseed crop, and the low‐value press cake that remains after ...
Jakob Skytte Thorsen, Deyang Xu, Barbara Ann Halkier   +2 more
wiley   +1 more source