Results 21 to 30 of about 70,182 (263)
Multi-locus assortment (MLA) for transgene dispersal and elimination in mosquito populations. [PDF]
PLoS ONE, 2009 BACKGROUND:Replacement of wild-type mosquito populations with genetically modified versions is being explored as a potential strategy to control vector-borne diseases.
Jason L Rasgon
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Nature Communications, 2022 Long hairpin RNA (hpRNA) transgenes are the most widely used RNAi technology in plants, but are potentially subject to self-induced transcriptional silencing.
Daai Zhang +7 more
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Nature Communications, 2021 Accumulating evidences point to a discrepancy in the epigenetic behaviour of transgenes and endogenous genes. Here, via characterization of mutants impaired in histone demethylases JMJ14 and IBM1, the authors show that transgenes and endogenous genes are
Nicolas Butel +11 more
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Measurement of Transgenes Copy Number in Wheat Plants Using Droplet Digital PCR
Bio-Protocol, 2022 Genetic transformation is a powerful method for the investigation of gene function and improvement of crop plants. The transgenes copy number in the transgenic line is involved in gene expression level and phenotypes.
Peng Liu +4 more
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Synthetic mammalian transgene negative autoregulation
Molecular Systems Biology, 2013 Biological networks contain overrepresented small‐scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative‐feedback loop, where a gene product represses its own transcription.
Vinay Shimoga +4 more
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Matrix metalloproteinase-20 over-expression is detrimental to enamel development: a Mus musculus model. [PDF]
PLoS ONE, 2014 Matrix metalloproteinase-20 (Mmp20) ablated mice have enamel that is thin and soft with an abnormal rod pattern that abrades from the underlying dentin.
Masashi Shin +8 more
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Frontiers in Genome Editing, 2023 Increased understanding of plant genetics and the development of powerful and easier-to-use gene editing tools over the past century have revolutionized humankind’s ability to deliver precise genotypes in crops.
Zuzana Kocsisova, Viktoriya Coneva
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New approaches for characterization of the genetic stability of vaccine cell lines
Human Vaccines & Immunotherapeutics, 2017 The genetic stability of cell lines is a critical analytical attribute required to demonstrate the quality of cells over time. During cell passage, mutations can arise in the genomic DNA, potentially leading to changes in the final vaccine product.
Siemon Ng, Lucy Gisonni-Lex, Ali Azizi
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eLife, 2016 Changes in chromosome number impair fitness by disrupting the balance of gene expression. Here we analyze mechanisms to compensate for changes in gene dose that accompanied the evolution of sex chromosomes from autosomes.
Bayly S Wheeler +5 more
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Biochemistry and Biophysics Reports, 2022 Human primary cells, including urine-derived cells (UCs), are an excellent source for generation of pluripotent stem cells (iPSCs) to model disease. However, replicative senescence starts early and shortens the time window for generation of iPSCs.
Matthias Weiand +4 more
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