Results 61 to 70 of about 80,448 (304)
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Российский паразитологический журнал, 2016 Metarhizium anisopliae is an entomopathogenic organism that is parasitic towards insects, including those that serve as vectors for human disease, including malaria parasite infected Anopheles mosquitoes.
C. N. WEIR, E. EWONG, G. F. KING
doaj
Cross-talk between posttranscriptionally silenced neomycin phosphotransferase II transgenes
, 2000 Tobacco plants containing a transgene locus with two chimeric neomycin phosphotransferase II (nptII) genes in tail-to-tail orientation (locus 1) show posttranscriptional gene silencing.
Kovařı́k, Ales +11 more
core +1 more source
Rescue of female sterility by transgenes used in this study.
, 2021 GFP-tagged Rhi, Del and Cuff transgenes as well as mKate2-tagged Rhi transgene driven by a putative rhi promoter fully rescue the female sterility of respective mutations. (TIF)
Alexei A. Aravin (8395794) +2 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
CellsThe stable and safe integration of exogenous DNA into the genome is crucial to both genetic engineering and gene therapy. Traditional transgenesis approaches, such as those using retroviral vectors, result in random genomic integration, posing the risk ...
Amer Ahmed +9 more
doaj +1 more source
Frontiers in Neural Circuits, 2013 The fruit fly Drosophila melanogaster represents a key model organism for analyzing how neuronal circuits regulate behavior. The mushroom body in the central brain is a particularly prominent brain region that has been intensely studied in several insect
Ulrike ePech +7 more
doaj +1 more source
Bioscientifica Proceedings, 2019 Single genes can now be added routinely to the genome of mice by molecular manipulation as simple Mendelian dominants; this complements the normal process of reproduction to give 'transgenic' animals. Success in ruminants is limited to a few examples in sheep and although gene expression has yet to be documented, there is every reason to expect that it
J P, Simons, R B, Land
openaire +2 more sources
Coincident sequence-specific RNA degradation of linked transgenes in the plant genome
, 2011 The expression of transgenes in plant genomes can be inhibited by either transcriptional gene silencing or posttranscriptional gene silencing (PTGS). Overexpression of the chalcone synthase-A (CHS-A) transgene triggers PTGS of CHS-A and thus results in ...
Masuta, C. +15 more
core +1 more source
Advanced Science, EarlyView.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source