Results 101 to 110 of about 50,997 (182)
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés +13 more
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MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
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Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
MedComm, Volume 7, Issue 2, February 2026.The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
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Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
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Targeting dCas9‐SunTag to a Susceptibility Gene Promoter Is Sufficient for CRISPR Interference
Plant Direct, Volume 10, Issue 2, February 2026.ABSTRACT Cassava production in sub‐Saharan Africa is severely impacted by diseases. Most pathogens require interaction with host susceptibility factors to complete their life cycles and cause disease. Targeted DNA methylation is an epigenetic strategy to alter gene expression in plants, and we previously reported that a zinc‐finger fused to DMS3 could ...
Zuh‐Jyh Daniel Lin +14 more
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Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors
Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings +6 more
wiley +1 more source
Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models
VIEW, Volume 7, Issue 1, February 2026.Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
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Traction force generation in Plasmodium sporozoites is modulated by a surface adhesin
Journal of Microscopy, Volume 301, Issue 2, Page 267-279, February 2026.Abstract Plasmodium sporozoites are the highly polarised and motile forms of the malaria parasite transmitted by mosquitoes to the vertebrate hosts. Sporozoites use myosin motors to generate retrograde flow of actin filaments. These are linked to plasma membrane spanning adhesins, which in turn bind to the extracellular environment, resulting in ...
Johanna Ripp +4 more
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Neuropathology, Volume 46, Issue 1, February 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón +3 more
wiley +1 more source
EFSA Journal, Volume 24, Issue 2, February 2026.Abstract The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase, EC 3.1.1.3) is produced with the genetically modified Trichoderma reseei strain AR‐822 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA.
EFSA Panel on Food Enzymes (FEZ) +17 more
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