Results 111 to 120 of about 50,997 (182)

Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment. [PDF]

Regul Toxicol Pharmacol
Yauk CL, Lynch AM, Dobrovolsky VN, Schuler M, Smith-Roe SL, Fitzgerald D, Higgins J, Honarvar N, Le Curieux F, Matsumura S, Minocherhomji S, Recio L, Salk JJ, Sugiyama KI, Suzuki T, Wills JW, Marchetti F.   +16 more
europepmc   +1 more source

Transgenic rodent gene mutation assays: performance characteristics and exploration of the effects of critical variables affecting the development of a standardized experimental protocol [PDF]

, 2018
openaire   +1 more source

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis. [PDF]

Arch Toxicol
Ashford AL, Nachmanson D, Wills JW, Higgins JE, Smith TH, Vavra KC, Dahalan FA, Howe J, Elloway JM, Salk JJ, Doherty A, Lynch AM.   +11 more
europepmc   +1 more source

Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†. [PDF]

Biol Reprod
LeBlanc DPM, Zhou G, Williams A, Meier MJ, Valentine CC, Salk JJ, Yauk CL, Marchetti F.   +7 more
europepmc   +1 more source

Guidelines for the assessment and control of mutagenic impurities in pharmaceuticals. [PDF]

Genes Environ
Honma M.
europepmc   +1 more source

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology. [PDF]

Front Toxicol
Barutcu AR, Bhattarai N, Samuel R, Scaglione J, Recio L.   +4 more
europepmc   +1 more source

Oxidative stress accelerates repeat sequence instability and base substitutions promoting gastrointestinal driver mutations in MSH2 deficient mice. [PDF]

Genes Environ
Ohno M, Takano N, Hidaka K, Sasaki F, Aoki Y, Nohmi T, Tsuzuki T.   +6 more
europepmc   +1 more source

Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities. [PDF]

Toxicol Sci
Guo X, Seo JE, Xu H, Yan J, Malhi P, Atrakchi AH, McGovern T, Davis Bruno KL, Heflich RH, Chen T.   +9 more
europepmc   +1 more source

Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications. [PDF]

BioData Min
Alnasser SM.
europepmc   +1 more source

Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir. [PDF]

Toxicol Sci
Escobar PA, Sobol Z, Miller RR, Ferry-Martin S, Stermer A, Jacob B, Muniappa N, Sanchez RI, Blanchard KT, Galijatovic-Idrizbegovic A, Amin RP, Troth SP.   +11 more
europepmc   +1 more source