Results 131 to 140 of about 4,740,665 (262)

Transient Expression of Flavivirus Structural Proteins in Nicotiana benthamiana. [PDF]

Vaccines (Basel), 2022
Asghar N, Melik W, Paulsen KM, Pedersen BN, Bø-Granquist EG, Vikse R, Stuen S, Andersson S, Strid Å, Andreassen ÅK, Johansson M.   +10 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development of <i>in planta</i> genome editing by transient expression of genome-editing tools in tomato. [PDF]

Front Genome Ed
Kobayashi M, Renhu N, Takahashi S, Choi S, Watanabe H, Fuhrmann-Aoyagi MB, Ezura H, Miura K.   +7 more
europepmc   +1 more source

Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells. [PDF]

Biomolecules, 2023
Kaipa JM, Krasnoselska G, Owens RJ, van den Heuvel J.   +3 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Transient expression of human interleukin-15 in <i>Nicotiana benthamiana</i>. [PDF]

Plant Biotechnol (Tokyo)
Mukai Y, Taguchi Y, Matsuo K.
europepmc   +1 more source

An Agrobacterium-Mediated Transient Expression Method for Functional Assay of Genes Promoting Disease in Monocots. [PDF]

Int J Mol Sci, 2023
Xu H, Chang Q, Huang L, Wei P, Song Y, Guo Z, Peng YL, Fan J.   +7 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A rapid Agrobacterium rhizogenes-mediated transient expression for assessing sgRNA efficiency in CRISPR-Act3.0 in tomato. [PDF]

Plant Cell Rep
Mostafa K, Scarano A, Abdulla MF, Hacıkamiloğlu S, Kurt O, Santino A, Kavas M.   +6 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source