Results 41 to 50 of about 665,407 (262)

De Novo Synthesis of Anticholinergic Hyoscyamine and Scopolamine in Nicotiana benthamiana Based on Elucidating Tropane Alkaloid Biosynthetic Pathway of Anisodus luridus

Agronomy
Anisodus luridus, a perennial herb belonging to the genus Anisodus of the Solanaceae family, is an important Tibetan medicinal plant that produces pharmaceutical tropane alkaloids (TAs) including hyoscyamine and scopolamine. Its high yield of hyoscyamine
Mengling Wen, Junlan Zeng, Fei Qiu, Fangyuan Zhang, Zhihua Liao   +4 more
doaj   +1 more source

Monoclonal Antibodies B38 and H4 Produced in Nicotiana benthamiana Neutralize SARS-CoV-2 in vitro

Frontiers in Plant Science, 2020
The ongoing coronavirus disease 2019 (COVID-19) outbreak caused by novel zoonotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially reported in Wuhan city, Hubei Province of China, in late December 2019.
Balamurugan Shanmugaraj, Balamurugan Shanmugaraj, Kaewta Rattanapisit, Kaewta Rattanapisit, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Waranyoo Phoolcharoen, Waranyoo Phoolcharoen   +7 more
doaj   +1 more source

Evaluation of plant-produced Clostridium perfringens type D epsilon toxoid in a vaccine against enterotoxaemia in sheep

Onderstepoort Journal of Veterinary Research, 2017
Enterotoxaemia (pulpy kidney) is a common bacterial disease of sheep caused by Clostridium perfringens type D epsilon toxin. It has mortality rates of up to 30% in non-vaccinated animals.
Tinyiko Mokoena, Ereck Chakauya, Michael Crampton, Boet Weyers, Malefa Tselanyane, Tsepo Tsekoa, Rachel Chikwamba   +6 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars, Anthony J Ricci, Grimm, Christian, Heller, Stefan, Anthony J. Ricci (212303), Ricci, Anthony J., Stefan Heller, Lars Becker (358879), Zhaohua Guo (383295), Zhaohua Guo, Stefan Heller (36641), Guo, Zhaohua, Lars Becker, Christian Grimm, Christian Grimm (84987)   +14 more
core   +1 more source

The Major Peanut Allergen Ara h 2 Produced in Nicotiana benthamiana Contains Hydroxyprolines and Is a Viable Alternative to the E. Coli Product in Allergy Diagnosis

Frontiers in Plant Science, 2021
Peanut allergy is a potentially life-threatening disease that is mediated by allergen-specific immunoglobulin E (IgE) antibodies. The major peanut allergen Ara h 2, a 2S albumin seed storage protein, is one of the most dangerous and potent plant ...
Öykü Üzülmez, Tanja Kalic, Tanja Kalic, Vanessa Mayr, Nina Lengger, Angelika Tscheppe, Christian Radauer, Christine Hafner, Christine Hafner, Wolfgang Hemmer, Heimo Breiteneder   +10 more
doaj   +1 more source

T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia, Tarique Hussain, Jeanne Dillenbeck, Matthew Hammer, Annette von Drygalski, Guy Young, Ayesha Zia   +6 more
wiley   +1 more source

Transient transfection of Cryptosporidium parvum using green fluorescent protein (GFP) as a marker [PDF]

, 2009
Cryptosporidium parvum is a protozoan parasite that infects a variety of mammals. The parasite has been shown to harbor a dsRNA virus (CPV) and in the present study, we have developed a CPV transient transfection system for this parasite by using green ...
Yu, X., Li, W., Li, J., Zhang, N., Liang, X., Zhang, X., Gong, P., Ma, G., Ryan, U.M.   +8 more
core   +1 more source

Transient Expression of Dengue Virus NS1 Antigen in Nicotiana benthamiana for Use as a Diagnostic Antigen

Frontiers in Plant Science, 2020
Dengue is a viral disease that represents a significant threat to global public health since billions of people are now at risk of infection by this mosquito-borne virus.
Lívia É. C. Marques, Bruno B. Silva, Rosa Fireman Dutra, Eridan O. P. Tramontina Florean, Rima Menassa, Maria Izabel F. Guedes   +5 more
doaj   +1 more source

Transcriptome-wide expression analysis of MYB gene family leads to functional characterization of flavonoid biosynthesis in fruit coloration of Ziziphus Mill

Frontiers in Plant Science, 2023
The Ziziphus mauritiana Lam. and Z. jujuba Mill. are the two most economically important members of the genus Ziziphus. The fruit color of Z. mauritiana remains green throughout fruit development in the majority of commercial cultivars, whereas its close
Noor Muhammad, Noor Muhammad, Zhi Luo, Zhi Luo, Xin Zhao, Xin Zhao, Meng Yang, Meng Yang, Zhiguo Liu, Zhiguo Liu, Mengjun Liu, Mengjun Liu   +11 more
doaj   +1 more source