Results 51 to 60 of about 11,438 (267)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Transient Overvoltage Security Region and Overvoltage Comprehensive Suppression Method for the Entire Fault Process in Renewable Energy Collection System Under Asymmetric Fault

Energies
During the asymmetric short-circuit period and the fault recovery stage of the renewable energy collection system, the non-fault phase and the PCC point show transient overvoltage characteristics, respectively, which threaten the safe and stable ...
Biyang Wang, Jieyi Chen, Shirui Liu, Nan Xia, Lei Luo   +4 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

A novel directional pilot protection method for EHV transmission lines based on S-transform and SVM

Discover Applied Sciences
To address the issues of insufficient reliability and low sensitivity of traveling-wave (TW)-based protection caused by fault condition attributes, i.e., fault resistance and fault angle, this paper proposes a novel directional pilot protection method ...
Zhenwei Guo, Yingcai Deng, Tong Zhang, Zebo Huang   +3 more
doaj   +1 more source

Transient Stability Analysis Method of Power System Based on Multi-source Data Drive

Taiyuan Ligong Daxue xuebao
Purposes At present, the data driven method represented by deep learning has been widely used in power transient stability analysis. However, the existing transient stability models for researching data driving have some problems, such as limited ...
Ying QU, Xiaoqing HAN, Xinyuan LIU, Xiaohui LU, Tao MENG, Ying ZHANG   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Single Terminal Transient Protection Scheme Based on Fuzzy Multi-criteria Fusion

Zhongguo dianli
The existing single-terminal transient protection schemes rely solely on single fault feature for fault identification, which leads to the poor identification reliability. This paper thus proposes a novel single-terminal transient protection scheme based
Meiling LUO, Zixiao LI, Tao ZHENG, Xiaojun YU, Jianyun WU, Haibin XIE   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Generic Parity-Based Concurrent Error Detection for Lightweight ARX Ciphers

IEEE Access, 2020
Cryptographic functions for constrained processing environments can be devised using lightweight cryptography. For use in safety relevant automotive applications where transient faults can occur at runtime the calculation of a cipher text requires ...
Sergei Bauer, Stefan Rass, Peter Schartner   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source