Results 41 to 50 of about 37,224,846 (202)

Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

Nature Communications, 2022
Ultrasound can be used to non-invasively control neuronal functions. Here the authors report the use of human Transient receptor potential ankyrin 1 (hsTRPA1) to achieve ultrasound sensitivity in mammalian cells, and show that it can be used to ...
Marc Duque, Corinne A. Lee-Kubli, Yusuf Tufail, Uri Magaram, Janki Patel, Ahana Chakraborty, Jose Mendoza Lopez, Eric Edsinger, Aditya Vasan, Rani Shiao, Connor Weiss, James Friend, Sreekanth H. Chalasani   +12 more
doaj   +1 more source

β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees:Protein complex critical for sodium channel activity is impaired by SCA5-associated mutations [PDF]

, 2014
Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival.
Perkins, Emma M., Clarkson, Yvonne L., Lyndon, Alastair R., Skehel, Paul A., Jackson, Mandy, Cairncross, Callum J., Lyndon, Alastair R.; id_orcid   +6 more
core   +1 more source

The role of transient receptor potential ankyrin 1 in age-related endothelial dysfunction

Experimental Gerontology, 2021
Oxidative stress plays a key role in age-related vascular disease. The present study aimed to investigate the role of an antioxidant channel, transient receptor potential ankyrin 1 (TRPA1), in age-related endothelial dysfunction. Human umbilical vein endothelial cells (HUVECs) were grown to induce replicative senescence, and 6-month-old young, 12-month-
Yi, Yang, Dan, Wang, Jindong, Wan, Fei, Ran, Lun, Yang, Shizhao, Chen, Fang, Wang, Sen, Liu, Xiaozhen, Dai, Peng, Zhou, Peijian, Wang   +10 more
openaire   +2 more sources

Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis [PDF]

Scientific Reports, 2020
AbstractPain evoked by visceral inflammation is often ‘referred’ to the somatic level. Transient receptor potential ankyrin 1 (TRPA1) has been reported to contribute to visceral pain-like behavior in dextran sulfate sodium (DSS)-evoked colitis. However, the role of TRPA1 in somatic component of hypersensitivity due to visceral inflammation is unknown ...
1. Jain P., Materazzi S., De Logu F., Rossi Degl’Innocenti D., Fusi C., Li Puma S., Marone I. M., Coppi E., Holzer P., Geppetti P., and Nassini R.   +10 more
openaire   +4 more sources

Biochemical and structural insights into FIH-catalysed hydroxylation of transient receptor potential ankyrin repeat domains [PDF]

, 2022
Transient Receptor Potential (TRP) channels have important roles in environmental sensing in animals. Human TRP subfamily A member 1 (TRPA1) is responsible for sensing allyl isothiocyanate (AITC) and other electrophilic sensory irritants.
Saward, Benjamin, Timperley, Christopher, Schofield, Christopher, Leissing, Thomas, Tumber, Anthony, Clifton, Ian, Hopkinson, Richard   +6 more
core   +1 more source

Regulation of vascular tone by transient receptor potential ankyrin 1 channels

, 2020
The Ca2+-permeable, non-selective cation channel, TRPA1 (transient receptor potential ankyrin 1), is the sole member of the ankyrin TRP subfamily. TRPA1 channels are expressed on the plasma membrane of neurons as well as non-neuronal cell types, such as vascular endothelial cells.
Pratish, Thakore, Sher, Ali, Scott, Earley   +2 more
openaire   +3 more sources

Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells

Scientific Reports, 2021
The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able to respond to noxious stimuli, reactive oxygen species, inflammatory cytokines or ...
Florentina Cojocaru, Tudor Şelescu, Dan Domocoş, Luminiţa Măruţescu, Gabriela Chiritoiu, Nicoleta-Raluca Chelaru, Simona Dima, Dan Mihăilescu, Alexandru Babes, Dana Cucu   +9 more
doaj   +1 more source

Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

Molecular Pain, 2007
Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C, Wang Weiya, Gao BaoXi, Tamir Rami, Klionsky Lana, Nishimura Nobuko, Gavva Narender R   +6 more
doaj   +1 more source

Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma. [PDF]

Int J Mol Sci, 2022
Oral squamous cell carcinoma (OSCC) is a common cancer with poor prognosis. Transient Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) receptors are non-selective cation channels expressed on primary sensory neurons and epithelial and immune ...
Kiss F, Kormos V, Szőke É, Kecskés A, Tóth N, Steib A, Szállási Á, Scheich B, Gaszner B, Kun J, Fülöp G, Pohóczky K, Helyes Z.   +12 more
europepmc   +2 more sources

Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease

Cellular and Molecular Gastroenterology and Hepatology, 2018
The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear.
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue   +11 more
doaj   +1 more source