Results 31 to 40 of about 37,224,846 (202)

Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review. [PDF]

Genes (Basel), 2023
Background and Objective: Chronic pain represents a major global health issue in terms of psycho-physiological, therapeutic, and economic burden, not limited to adults but also to the pediatric age. Despite its great impact, its molecular mechanisms have still not been completely unraveled.
Celsi F, Peri F, Cavasin J, Zupin L, Cozzi G, Barbi E, Crovella S.   +6 more
europepmc   +4 more sources

STIM1 functionally couples to transient receptor potential ankyrin 1 contributing to nociception. [PDF]

Pain
Abstract STIM1 is a calcium sensor that can sense calcium level changes in the endoplasmic reticulum (ER) and respond to extracellular stimuli. We have reported that STIM1 is expressed in nociceptors. However, its functional significance remains unclear.
Mei Y, Birla H, Lee BH, Li Z, Rai V, Zhang I, Huo X, Yi A, Zhang Q, Li D, Zhong Y, Wang F, Yasin B, Apai C, Rohacs T, Tao YX, Bekker A, Hu H.   +17 more
europepmc   +3 more sources

Etodolac activates and desensitizes transient receptor potential ankyrin 1 [PDF]

Journal of Neuroscience Research, 2013
The transient receptor potential ankyrin 1 (TRPA1) channel is well known as a sensor to environmental irritant compounds, cold, and endogenous proalgesic agents. TRPA1 is expressed on sensory neurons and is involved in pain modulation. Etodolac is a cyclooxygenase (COX)‐2 inhibitor that belongs to the class of nonsteroidal anti‐inflammatory drugs ...
Shenglan, Wang, Yi, Dai, Yoko, Kogure, Satoshi, Yamamoto, Wensheng, Zhang, Koichi, Noguchi   +5 more
openaire   +2 more sources

Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease [PDF]

Journal of Neuroinflammation, 2016
Transient receptor potential ankyrin 1 (TRPA1) channel plays an important role in pain and inflammation. However, little is known about the significance of the TRPA1 channel in the pathophysiology of Alzheimer's disease (AD).Wild-type (WT), TRPA1(-/-), amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic (APP/PS1 Tg) mice, the mouse model of ...
Lee, Kuan-I, Lee, Hsueh-Te, Lin, Hui-Ching, Tsay, Huey-Jen, Tsai, Feng-Chuan, Shyue, Song-Kun, Lee, Tzong-Shyuan   +6 more
openaire   +2 more sources

New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel [PDF]

Scientific Reports, 2020
AbstractThe transient receptor potential (TRP) channels family are cationic channels involved in various physiological processes as pain, inflammation, metabolism, swallowing function, gut motility, thermoregulation or adipogenesis. In the oral cavity, TRP channels are involved in chemesthesis, the sensory chemical transduction of spicy ingredients ...
Legrand, Coline, Merlini, Jenny Meylan, de Senarclens-Bezençon, Carole, Michlig, Stéphanie   +3 more
openaire   +2 more sources

Molecular Mechanisms of Dicentra Formosa’s Analgesic Effect

Medicine in Drug Discovery, 2020
Background: Surgeons, Native Americans, and Eclectics have all sworn to the multiple healing properties including anthelmintic, analgesic, and anti-cancer effects that Dicentra Formosa possesses.
Royale Gray-Lee, Jesun Lee
doaj   +1 more source

Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

Frontiers in Pharmacology, 2021
Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions.
Ádám Horváth, Ádám Horváth, Maja Payrits, Maja Payrits, Anita Steib, Anita Steib, Boglárka Kántás, Boglárka Kántás, Tünde Biró-Süt, Tünde Biró-Süt, János Erostyák, János Erostyák, Géza Makkai, Géza Makkai, Éva Sághy, Éva Sághy, Éva Sághy, Zsuzsanna Helyes, Zsuzsanna Helyes, Éva Szőke, Éva Szőke   +20 more
doaj   +1 more source

Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach [PDF]

, 2011
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...

core   +2 more sources

Activation of transient receptor potential ankyrin 1 by quercetin and its analogs [PDF]

Bioscience, Biotechnology, and Biochemistry, 2016
Abstract The agonistic activity of quercetin and its analogs towards the transient receptor potential ankyrin 1 (TRPA1) has been experimentally investigated. The human TRPA1 was expressed in HEK293T cells using a tetracycline-inducible system.
Toshiyuki, Nakamura, Noriyuki, Miyoshi, Takeshi, Ishii, Miyu, Nishikawa, Shinichi, Ikushiro, Tatsuo, Watanabe   +5 more
openaire   +2 more sources

X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation

Molecular Pain, 2019
Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this
Su Cun-Jin, Xu Jian-Hao, Liu Xu, Zhao Feng-Lun, Pan Jie, Shi Ai-Ming, Hu Duan-Min, Yu Yun-Li, Liu Tong, Zhang Yu-Song   +9 more
doaj   +1 more source