Results 31 to 40 of about 11,052 (171)

Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

Nature Communications, 2022
Ultrasound can be used to non-invasively control neuronal functions. Here the authors report the use of human Transient receptor potential ankyrin 1 (hsTRPA1) to achieve ultrasound sensitivity in mammalian cells, and show that it can be used to ...
Marc Duque, Corinne A. Lee-Kubli, Yusuf Tufail, Uri Magaram, Janki Patel, Ahana Chakraborty, Jose Mendoza Lopez, Eric Edsinger, Aditya Vasan, Rani Shiao, Connor Weiss, James Friend, Sreekanth H. Chalasani   +12 more
doaj   +1 more source

The role of transient receptor potential ankyrin 1 in age-related endothelial dysfunction

Experimental Gerontology, 2021
Oxidative stress plays a key role in age-related vascular disease. The present study aimed to investigate the role of an antioxidant channel, transient receptor potential ankyrin 1 (TRPA1), in age-related endothelial dysfunction. Human umbilical vein endothelial cells (HUVECs) were grown to induce replicative senescence, and 6-month-old young, 12-month-
Yi, Yang, Dan, Wang, Jindong, Wan, Fei, Ran, Lun, Yang, Shizhao, Chen, Fang, Wang, Sen, Liu, Xiaozhen, Dai, Peng, Zhou, Peijian, Wang   +10 more
openaire   +2 more sources

Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis [PDF]

Scientific Reports, 2020
AbstractPain evoked by visceral inflammation is often ‘referred’ to the somatic level. Transient receptor potential ankyrin 1 (TRPA1) has been reported to contribute to visceral pain-like behavior in dextran sulfate sodium (DSS)-evoked colitis. However, the role of TRPA1 in somatic component of hypersensitivity due to visceral inflammation is unknown ...
1. Jain P., Materazzi S., De Logu F., Rossi Degl’Innocenti D., Fusi C., Li Puma S., Marone I. M., Coppi E., Holzer P., Geppetti P., and Nassini R.   +10 more
openaire   +4 more sources

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]

PLoS ONE, 2012
BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B Damholt, Pierangelo Geppetti, Serena Materazzi   +15 more
doaj   +1 more source

Muscle pain induced by static contraction is modulated by transient receptor potential vanilloid 1 and ankyrin 1 receptors

Brazilian Journal of Pharmaceutical Sciences, 2022
Molecular mechanisms involved in the development of muscle pain induced by static contraction are not completely elucidated. This study aimed to evaluate the involvement of the transient receptor potential vanilloid 1 (TRPV1) and the transient receptor ...
Carolina Ocanha Jorge, Bruna de Melo-Aquino, Diogo Francisco da Silva dos Santos, Maria Cláudia Gonçalves de Oliveira   +3 more
doaj   +1 more source

Regulation of vascular tone by transient receptor potential ankyrin 1 channels

, 2020
The Ca2+-permeable, non-selective cation channel, TRPA1 (transient receptor potential ankyrin 1), is the sole member of the ankyrin TRP subfamily. TRPA1 channels are expressed on the plasma membrane of neurons as well as non-neuronal cell types, such as vascular endothelial cells.
Pratish, Thakore, Sher, Ali, Scott, Earley   +2 more
openaire   +3 more sources

Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells

Scientific Reports, 2021
The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able to respond to noxious stimuli, reactive oxygen species, inflammatory cytokines or ...
Florentina Cojocaru, Tudor Şelescu, Dan Domocoş, Luminiţa Măruţescu, Gabriela Chiritoiu, Nicoleta-Raluca Chelaru, Simona Dima, Dan Mihăilescu, Alexandru Babes, Dana Cucu   +9 more
doaj   +1 more source

Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

Molecular Pain, 2007
Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C, Wang Weiya, Gao BaoXi, Tamir Rami, Klionsky Lana, Nishimura Nobuko, Gavva Narender R   +6 more
doaj   +1 more source

Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease

Cellular and Molecular Gastroenterology and Hepatology, 2018
The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear.
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue   +11 more
doaj   +1 more source

Methylglyoxal activates the human transient receptor potential ankyrin 1 channel

The Journal of Toxicological Sciences, 2012
Methylglyoxal (MG) is an endogenous carbonyl compound that is produced in large quantity under hyperglycemic conditions, which are believed to contribute to the development of diabetic neuropathy. However, the mechanism by which this occurs and the molecular targets of MG are unclear.
Ohkawara, Susumu, Tanaka-Kagawa, Toshiko, Furukawa, Yoko, Jinno, Hideto   +3 more
openaire   +2 more sources