Transient receptor potential Ankyrin 1: structure, function and ligands [PDF]
Research Results in Pharmacology, 2022 Introduction: Transient receptor potential ankyrin 1 (TRPA1) is a protein expressed in many living organisms. During the study of TRPA1, its unique biological role as a universal and polymodal sensor of various altering agents was found.
Natalia V. Pyatigorskaya +3 more
doaj +6 more sources
Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in gout. [PDF]
PLoS ONE, 2015 INTRODUCTION:In gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor Poten-tial Ankyrin 1 (TRPA1), an ion channel mediating nociceptive signals ...
Lauri J Moilanen +4 more
doaj +5 more sources
Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function [PDF]
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
doaj +3 more sources
Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva. [PDF]
Pain, 2022 Abstract Arthropods are the largest group of living organisms, and among them, mosquitoes spread parasites and viruses causing deadly diseases. They can easily spread these pathogens because of their painless skin piercing. Although the lack of pain is mainly due to the thinness of their fascicle, it is possible that mosquito saliva ...
Derouiche S +5 more
europepmc +4 more sources
Transient receptor potential ankyrin 1 channel: An evolutionarily tuned thermosensor. [PDF]
Physiol Res, 2021 The discovery of the role of the transient receptor potential ankyrin 1 (TRPA1) channel as a polymodal detector of cold and pain-producing stimuli almost two decades ago catalyzed the consequent identification of various vertebrate and invertebrate orthologues.
Sinica V, Vlachová V.
europepmc +3 more sources
Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review). [PDF]
Exp Ther Med, 2021 Calcium (Ca2+) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca2+ homeostasis may cause human diseases. Usually known as a member of the transient receptor potential (TRP) family, TRP ankyrin 1 (TRPA1) is the only member of the ankyrin subfamily ...
Hu F, Song X, Long D.
europepmc +3 more sources
Transient Receptor Potential Ankyrin 1 (TRPA1)—An Inflammation-Induced Factor in Human HaCaT Keratinocytes [PDF]
International Journal of Molecular Sciences, 2021 Samu Luostarinen +2 more
exaly +2 more sources
Reactive oxygen species-specific characteristics of transient receptor potential ankyrin 1 receptor and its pain modulation [PDF]
Journal of Medicine and Life Science, 2023 Transient receptor potential ankyrin 1 (TRPA1) receptors are major polymodal nociceptors that generate primary pain responses in the peripheral nerve endings of the dorsal root ganglion neurons.
Hyun-Ji Yoon, Sung-Cherl Jung
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Osteoarthritis (OA) is a chronic joint disease with increasing prevalence. Chondrocytes (CHs) are highly differentiated end-stage cells with a secretory phenotype that keeps the extracellular matrix (ECM) balanced and the cartilage environment stable ...
Hui Che +10 more
doaj +1 more source
Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]
PLoS ONE, 2011 Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder +21 more
doaj +1 more source