Journal of Pharmacological Sciences, 2020 Cellular dielectric spectroscopy (CDS) is a novel technology enabling pharmacological evaluation of multiple receptor types with a label-free cell-based assay.
Kanako Miyano +11 more
doaj +2 more sources
Characterization of a Ligand Binding Site in the Human Transient Receptor Potential Ankyrin 1 Pore [PDF]
Biophysical Journal, 2013 The pharmacology and regulation of Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel activity is intricate due to the physiological function as an integrator of multiple chemical, mechanical, and temperature stimuli as well as differences in ...
Klement, Göran +7 more
core +4 more sources
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception
American Journal of Physiology-Cell Physiology, 2011 Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca2+-permeant, nonselective cationic channel. It is predominantly expressed in the C afferent sensory nerve fibers of trigeminal and dorsal root ganglion neurons and is highly coexpressed with ...
Fátima Pimentel +8 more
core +4 more sources
Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva. [PDF]
Pain, 2022 Abstract Arthropods are the largest group of living organisms, and among them, mosquitoes spread parasites and viruses causing deadly diseases. They can easily spread these pathogens because of their painless skin piercing. Although the lack of pain is mainly due to the thinness of their fascicle, it is possible that mosquito saliva ...
Derouiche S +5 more
europepmc +4 more sources
Transient receptor potential ankyrin 1 channel: An evolutionarily tuned thermosensor. [PDF]
Physiol Res, 2021 The discovery of the role of the transient receptor potential ankyrin 1 (TRPA1) channel as a polymodal detector of cold and pain-producing stimuli almost two decades ago catalyzed the consequent identification of various vertebrate and invertebrate orthologues.
Sinica V, Vlachová V.
europepmc +3 more sources
Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review). [PDF]
Exp Ther Med, 2021 Calcium (Ca2+) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca2+ homeostasis may cause human diseases. Usually known as a member of the transient receptor potential (TRP) family, TRP ankyrin 1 (TRPA1) is the only member of the ankyrin subfamily ...
Hu F, Song X, Long D.
europepmc +3 more sources
Desflurane Post-treatment Reduces Hypoxic-ischemic Brain Injury via Reducing Transient Receptor Potential Ankyrin 1 in Neonatal Rats [PDF]
Neuroscience, 2023 Zhiyi Zuo, Aobing Cheng
exaly +2 more sources
Reactive oxygen species-specific characteristics of transient receptor potential ankyrin 1 receptor and its pain modulation [PDF]
Journal of Medicine and Life Science, 2023 Transient receptor potential ankyrin 1 (TRPA1) receptors are major polymodal nociceptors that generate primary pain responses in the peripheral nerve endings of the dorsal root ganglion neurons.
Hyun-Ji Yoon, Sung-Cherl Jung
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Osteoarthritis (OA) is a chronic joint disease with increasing prevalence. Chondrocytes (CHs) are highly differentiated end-stage cells with a secretory phenotype that keeps the extracellular matrix (ECM) balanced and the cartilage environment stable ...
Hui Che +10 more
doaj +1 more source
Inhibition of Dorsal Root Ganglia Transient Receptor Potential Ankyrin 1 Upregulation Contributes to the Protective Effect of Morphine Against Gastric Mucosal Damage Induced by Water-Immersion Restraint Stress. [PDF]
Turk J GastroenterolBackground/Aims: The pathogenesis mechanism of acute gastric mucosal lesions (AGML) is still unclear; further exploration is urgently needed to find a new therapeutic target.
Jiang Q +7 more
europepmc +2 more sources