Results 161 to 170 of about 28,002 (191)

Transient receptor potential ankyrin 1 (TRPA1) modulators: Recent update and future perspective.

European journal of medicinal chemistry, 2023
The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that senses irritant chemicals. Its activation is closely associated with pain, inflammation, and pruritus.
Zeliang Hu, Ya Zhang, Wenhan Yu, Junjie Li, Jiaqi Yao, Jifa Zhang, Jiaxing Wang, Chengdi Wang   +7 more
semanticscholar   +1 more source

Satellite glial cells in sensory ganglia express functional transient receptor potential ankyrin 1 that is sensitized in neuropathic and inflammatory pain

Molecular Pain, 2020
Transient receptor potential ankyrin 1 (TRPA1) is well documented as an important molecule in pain hypersensitivity following inflammation and nerve injury and in many other cellular biological processes. Here, we show that TRPA1 is expressed not only by
Bin Pan, Hongwei Yu, Hongwei Yu
exaly   +2 more sources

Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists

Pharmaceutical Patent Analyst, 2015
The transient receptor potential ankyrin 1 (TRPA1) channel is an irritant sensor highly expressed on nociceptive neurons. The clinical use of TRPA1 antagonists is based on the concept that TRPA1 is active during disease states like neuropathic pain.
PRETI, Delia, SAPONARO, Giulia, Szallasi, Arpad   +2 more
openaire   +3 more sources

Activation of transient receptor potential ankyrin 1 by eugenol

Neuroscience, 2014
Eugenol is a bioactive plant extract used as an analgesic agent in dentistry. The structural similarity of eugenol to cinnamaldehyde, an active ligand for transient receptor potential ankyrin 1 (TRPA1), suggests that eugenol might produce its effect via TRPA1, in addition to TRPV1 as we reported previously.
G. Chung, S.T. Im, Y.H. Kim, S.J. Jung, M.-R. Rhyu, S.B. Oh   +5 more
openaire   +2 more sources

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.

Journal of Medicinal Chemistry, 2021
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interest as
Jack A. Terrett, Huifen Chen, D. Shore, Elisia Villemure, R. Larouche-Gauthier, Martin Déry, Francis Beaumier, Léa Constantineau-Forget, C. Grand-Maître, Luce Lépissier, Stephane Ciblat, C. Sturino, Yong Chen, Baihua Hu, A. Lu, Yunli Wang, A. Cridland, Stuart I Ward, D. Hackos, Rebecca M. Reese, S. Shields, Jun Chen, A. Balestrini, Lorena Riol-Blanco, Wyne P. Lee, John Liu, Eric Suto, Xiumin Wu, Juan Zhang, J. Ly, Hank La, Kevin M Johnson, M. Baumgardner, K. Chou, A. Rohou, L. Rougé, B. Safina, Steven Magnuson, M. Volgraf   +38 more
semanticscholar   +1 more source

Expression of Transient Receptor Potential Ankyrin 1 in Human Dental Pulp

Journal of Endodontics, 2012
Transient receptor potential ankyrin 1 (TRPA1) is activated by noxious cold (
Yun Sook, Kim, Hoon Kap, Jung, Tae Kyung, Kwon, Chin Soo, Kim, Jin Hyun, Cho, Dong Kuk, Ahn, Yong Chul, Bae   +6 more
openaire   +2 more sources

Norterpene Cyclic Peroxides from the Marine Sponge Diacarnus spinipoculum, Inhibitors of Transient Receptor Potential Ankyrin 1.

Journal of Natural Products
Bioassay-guided isolation of the extract from the marine sponge Diacarnus spinipoculum showing inhibitory activity against human transient receptor potential ankyrin 1 (hTRPA1) resulted in the isolation of 12 norditerpene cyclic peroxides (1-12) and ...
Yeonwoo Cho, Chinmayee Bawkar, Jung Mi Hyun, Myung Jin Song, Kwiwan Jeong, Yeon-Ju Lee   +5 more
semanticscholar   +1 more source

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

Neuroscience, 2011
Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that paclitaxel may release mast cell tryptase, which activates protease-activated receptor 2 (PAR2) and, subsequently, protein kinases A and C, resulting in mechanical and thermal (both heat and cold ...
Y, Chen, C, Yang, Z J, Wang
openaire   +2 more sources

Transient receptor potential ankyrin 1 (TRPA1)-mediated cough

European Respiratory Journal, 2011
TRPA1 detects many endogenous inflammatory and environmental pollutant molecules. Previous studies implicated TRPA1 as a drug target for antitussive therapy. We evaluated relative efficacy of the TRPA1 activation in inducing cough in guinea pigs.
Mariana Brozmanova, Lenka Mazurova, Fei Ru, Milos Tatar, Marian Kollarik   +4 more
openaire   +1 more source

Transient Receptor Potential Ankyrin 1 Channel Alters Transforming Growth Factor Beta 1/Smad Signaling in Rat Vocal Fold Fibroblasts

The Laryngoscope
Vocal fold scar remains a therapeutic challenge. Vocal fold fibroblasts (VFFs) secrete extracellular matrix (ECM), and transforming growth factor‐beta 1 (TGF‐β1)‐mediated fibroblast to myofibroblast differentiation is central to the development of ...
Hiroki Matsushita, S. Mukudai, K. Hashimoto, M. Kaneko, Y. Sugiyama, R. Branski, Shigeru Hirano   +6 more
semanticscholar   +1 more source