Results 141 to 150 of about 37,224,805 (160)
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Neuroscience, 2011
Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that paclitaxel may release mast cell tryptase, which activates protease-activated receptor 2 (PAR2) and, subsequently, protein kinases A and C, resulting in mechanical and thermal (both heat and cold ...
Y, Chen, C, Yang, Z J, Wang
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Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that paclitaxel may release mast cell tryptase, which activates protease-activated receptor 2 (PAR2) and, subsequently, protein kinases A and C, resulting in mechanical and thermal (both heat and cold ...
Y, Chen, C, Yang, Z J, Wang
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Transient receptor potential ankyrin 1 (TRPA1)-mediated cough
European Respiratory Journal, 2011TRPA1 detects many endogenous inflammatory and environmental pollutant molecules. Previous studies implicated TRPA1 as a drug target for antitussive therapy. We evaluated relative efficacy of the TRPA1 activation in inducing cough in guinea pigs.
Mariana Brozmanova +4 more
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Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine
Gastroenterology, 2011Transient receptor potential ankyrin (TRPA) 1, an excitatory ion channel expressed by sensory neurons, mediates somatic and visceral pain in response to direct activation or noxious mechanical stimulation. Although the intestine is routinely exposed to irritant alimentary compounds and inflammatory mediators that activate TRPA1, there is no direct ...
Daniel P, Poole +9 more
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Anesthesia & Analgesia, 2015
The transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1), which are expressed in sensory neurons, are polymodal nonselective cation channels that sense noxious stimuli. Recent reports showed that these channels play important roles in inflammatory, neuropathic, or cancer pain, suggesting that they may ...
Kanako, Miyano +9 more
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The transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1), which are expressed in sensory neurons, are polymodal nonselective cation channels that sense noxious stimuli. Recent reports showed that these channels play important roles in inflammatory, neuropathic, or cancer pain, suggesting that they may ...
Kanako, Miyano +9 more
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Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1
Neuroscience Letters, 2011Noxious cold reduces pruritus and transient receptor potential ankyrin subfamily member 1 (TRPA1), a non-selective cation channel, is known as a noxious cold-activated ion channel. Recent findings implicated the involvement of TRPA1 in pain induced by endothelin-1 (ET-1). Therefore, we evaluated its potential role in pruritus induced by ET-1.
Jiexian, Liang, Qing, Ji, Wenjin, Ji
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Role of Transient Receptor Potential Ankyrin 1 in Gastric Accommodation in Conscious Guinea Pigs
The Journal of Pharmacology and Experimental Therapeutics, 2012We report the establishment of a new model for measuring gastric tone and liquid meal-induced accommodation in conscious guinea pigs and the role played by transient receptor potential ankyrin 1 (TRPA1). An indwelling polyethylene bag was placed in proximal stomachs of 5-week-old male Hartley guinea pigs. Gastric tone was measured by distending the bag
Junichi, Koseki +8 more
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Transient Receptor Potential Ankyrin 1 in Diabetes
2019Diabetic neuropathy (DN) is a common complication of diabetes, which is often associ-ated with a loss of peripheral sensitivity, but pain is also a common symptom and early manifestation of DN. Detailed mechanisms responsible for the neuropathy and the painful symptoms in diabetes are unknown.
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Human Transient Receptor Potential Ankyrin 1 Channel: Structure, Function, and Physiology
The transient receptor potential ion channel TRPA1 is a Ca2+-permeable nonselective cation channel widely expressed in sensory neurons, but also in many nonneuronal tissues typically possessing barrier functions, such as the skin, joint synoviocytes, cornea, and the respiratory and intestinal tracts.Viktorie, Vlachova +2 more
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Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015–2019)
Expert Opinion on Therapeutic Patents, 2020Huifen Chen, Jack Terrett
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