Results 131 to 140 of about 28,002 (191)
Interactive segmentation of membrane and membrane‐mimic densities in cryo‐EM maps
Acta Crystallographica Section D, Volume 82, Issue 8, Page 848-861, August 2026.SURFER performs automated segmentation of contextual membrane and membrane‐mimic density in cryo‐EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map‐visualization workflows ...
Alok Bharadwaj +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4610-4627, August 2026.Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber +8 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Clinical Endocrinology, Volume 105, Issue 2, Page 197-204, August 2026.ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore +6 more
wiley +1 more source
14‐3‐3 proteins: Central hubs in plant development and stress adaptation
Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 3107-3132, August 2026.This review highlights recent advances elucidating the important roles of 14‐3‐3 proteins in regulating phytohormone networks, biotic and abiotic stress tolerance, growth‐defense trade‐offs, and evolutionary adaptations. Furthermore, it provides a forward‐looking perspective on 14‐3‐3 biology and the development of climate‐resilient smart crops under ...
Jiale Yuan +6 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 8, August 2026.This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley +1 more source
Physiological mechanisms and therapeutic targets in chronic cough
Physiological Reports, Volume 14, Issue 15, August 2026.Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown +3 more
wiley +1 more source
PharmaceuticalsObjectives: Transient Receptor Potential Ankyrin 1 (TRPA1) has emerged as a stress-responsive ion channel involved in calcium homeostasis, redox signaling, migration, and cancer cell survival; however, the therapeutic relevance of TRPA1 activation versus
Murat Çakır +3 more
doaj +1 more source
Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens. [PDF]
J Poult Sci, 2022 Kawabata F +5 more
europepmc +1 more source
Transient Receptor Potential Ankyrin 1 as a Target for Perioperative Pain Management [PDF]
Anesthesiology, 2012 openaire +2 more sources