Results 101 to 110 of about 10,656,275 (241)

TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons

, 2009
Stuart M. Brierley, Andrea M. Harrington, Patrick A. Hughes, Joel Castro, Amanda J. Page, David P. Corey, Kelvin Y. Kwan, Grigori Y. Rychkov & L.
Corey, D., Page, A., Rychkov, G., Harrington, A., Kwan, K., Brierley, S., Blackshaw, L., Hughes, P.   +7 more
core  

Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients

, 2019
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca2+).
Balinas, C, Cabanas, H, Staines, D, Marshall-Gradisnik, S   +3 more
core   +1 more source

Transient receptor potential channels and energy homeostasis

Trends in Endocrinology & Metabolism, 2013
Transient receptor potential (TRP) channels are members of an ancient class of ion channels that are present in most mammalian tissues. Consistent with their wide tissue distribution, TRPs are capable of influencing diverse physiological processes including adipocyte function, energy intake and energy expenditure. TRPs function as transduction channels
openaire   +3 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Regulation of transient receptor potential (TRP) channels by phosphoinositides [PDF]

, 2007
This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms.
Rohacs, Tibor, Bernd Nilius, Nilius, Bernd, Tibor Rohacs   +3 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

, 2011
Isabel Devesa1, Rosa Planells-Cases2, Gregorio Fernández-Ballester1, José Manuel González-Ros1, Antonio Ferrer-Montiel1, Asia Fernández-Carvajal11Instituto de Biología Molecular y Celular ...
Fernández-Carvajal AM, Devesa I, Ferrer-Montiel AV, González-Ros JM, Planells-Cases R, Fernández-Ballester GJ   +5 more
core  

Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson’s disease

Parkinson’s disease (PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium (Ca2+) homeostasis and the subsequent development of
Saeed, Iqira, Ma, Linlin, Iqira Saeed, Linlin Ma   +3 more
core   +1 more source

Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants. [PDF]

Gulf War Illness (GWI) is a chronic condition characterized by multisystem symptoms that still affect up to one-third of veterans who engaged in combat in the Gulf War three decades ago.
James N Baraniuk, Katsuhiko Muraki, Muraki, Katsuhiko, Baraniuk, James N, Sonya Marshall-Gradisnik, Natalie Eaton-Fitch, Eaton-Fitch, Natalie, Marshall-Gradisnik, Sonya, Etianne Martini Sasso, Smith, Peter, Peter Smith, Sasso, Etianne Martini   +11 more
core   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation [PDF]

, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Ute Woelfle, Kristina Leuner, Schempp, Christoph M., Kraus, Margarethe, Walter E Müller, Harteneck Christian, Christoph M. Schempp, Walter E. Müller, Margarethe Kraus, Harteneck, Christian, Beschmann, Heike, Beschmann, Heike A., Boehncke, Wolf-Henning, Beschmann Heike, Boehncke Wolf-Henning, Schempp Christoph M., Kraus Margarethe, Christoph M Schempp, Schempp, Christoph Mathis, Wolf-Henning Boehncke, Heike Beschmann, Christian Harteneck, Woelfle Ute, Leuner Kristina, Leuner, Kristina, Wölfle, Ute, Müller Walter E., Woelfle, Ute, Müller, Walter E.   +28 more
core   +1 more source