Results 141 to 150 of about 103,120 (254)

Pharmacologically targeting transient receptor potential channels for seizures and epilepsy: Emerging preclinical evidence of druggability. [PDF]

Pharmacol Ther, 2023
Jiang J, Yu Y.
europepmc   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Somatosensory Functions of Melastatin Transient-Receptor Potential Channels in the Teeth: Molecular Basis for Thermal Dentine Hypersensitivity. [PDF]

Dent J (Basel)
Méndez R, Martín-Cruces J, Anache M, Teulé-Trull M, García-Mesa Y, Cuendias P, Vega JA, Cobo T.   +7 more
europepmc   +1 more source

Involvement of transient receptor potential channels in ocular diseases: a narrative review. [PDF]

Ann Transl Med, 2022
Yang TJ, Yu Y, Yang JY, Li JJ, Zhu JY, Vieira JAC, Jiang Q.   +6 more
europepmc   +1 more source

Ionic Precursors Transformed Into Vinyl Acetate Synthesis Catalyst via Reaction‐Driven Restructuring

Advanced Functional Materials, EarlyView.
This work demonstrates that a simple physical mixture of Pd and Au ionic precursors, KOAc promoter, and SiO2 support can transform into a highly active vinyl acetate synthesis catalyst through reaction‐driven restructuring. The results highlight reaction‐induced restructuring as an innovative and sustainable catalyst design strategy.
Byeong Jun Cha, Welman C. Elias, Hunter P. Jacobs, Kimberly N. Heck, Saghar Rezaie, Sadegh Yazdi, Kiheon Hong, Justin J. Dodson, Laiyuan Chen, Sean G. Mueller, Steven R. Alexander, Michael S. Wong   +11 more
wiley   +1 more source

Transient receptor potential channels as key regulators of cell death in atherosclerosis. [PDF]

Front Immunol
Zhang Y, Wang W, Li X, Li X, Zheng L.
europepmc   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Physiological functions and pharmacological targeting of transient receptor potential channels. [PDF]

Pharmacol Rev
Chubanov V, Grimm C, Hill K, Schaefer M, Köttgen M, Storch U, Mederos Y Schnitzler M, Kudrina V, Erbacher A, Gudermann T.   +9 more
europepmc   +1 more source

Transient Receptor Potential Channels: Important Players in Ocular Pain and Dry Eye Disease. [PDF]

Pharmaceutics, 2022
Fakih D, Migeon T, Moreau N, Baudouin C, Réaux-Le Goazigo A, Mélik Parsadaniantz S.   +5 more
europepmc   +1 more source

Chemically Fueled Systems Chemistry Across Length Scales

Advanced Functional Materials, EarlyView.
Chemically fueled reaction cycles regulate processes through single and multiple catalytic sites on the molecular and assembly scale. This gives rise to unique kinetically controlled properties/functions like spatio‐temporal catalysis, oscillations, optical properties, and perform work.
Brigitte A. K. Kriebisch, Job Boekhoven
wiley   +1 more source