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Transient Receptor Potential Channels in neuropathic pain
Current Opinion in Pharmacology, 2017Neuropathic pain caused by disease or dysfunction of the nervous system is one of the most difficult pain conditions to treat. Symptoms include a hypersensitivity to mechanical and thermal stimuli, processed by specialized nociceptors that constitute the first line of defence of the somatosensory system.
Lilian, Basso, Christophe, Altier
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An overview on transient receptor potential channels superfamily
Behavioural Pharmacology, 2019The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participate in virtually every sensory ...
Merab G, Tsagareli, Ivliane, Nozadze
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Transient receptor potential channels as drug targets
Expert Opinion on Therapeutic Targets, 2007The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney.
Dayne Y, Okuhara +2 more
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Transient receptor potential channels and occupational exposure
Current Opinion in Allergy & Clinical Immunology, 2014The discovery that a number of transient receptor potential (TRP) channels are expressed in a subpopulation of primary sensory neurons innervating the upper and lower airways as well as in nonneuronal cells in the airways and lungs has initiated a quest for the understanding of their role in the physiology and pathophysiology of the respiratory tract ...
Geppetti P, Patacchini R, Nassini R.
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Transient Receptor Potential Channels
2011Volume 696 SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICALSYSTEMSEdited by Hamid R. Arabnia and Quoc-Nam TranVolume 697 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VIIEdited by Andrew Pollard, Adam Finn, and Nigel CurtisVolume 698 BIO-FARMS FOR NUTRACEUTICALS: FUNCTIONAL FOODAND SAFETY CONTROL BY BIOSENSORSMaria Teresa Giardi, Giuseppina Rea and ...
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Transient receptor potential channels in bladder function
Acta Physiologica, 2012AbstractThe transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons.
Avelino, A. +6 more
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Transient Receptor Potential Channels in Vascular Mechanotransduction
American Journal of HypertensionAbstract Transmural pressure and shear stress are mechanical forces that profoundly affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure ...
Alfredo Sanchez Solano +3 more
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Transient receptor potential channels and vascular function
Clinical Science, 2010TRP (transient receptor potential) channels play important roles in the regulation of normal and pathological cellular function. In the vasculature, TRP channels are present both in ECs (endothelial cells) and vascular SMCs (smooth muscle cells) and contribute to vasomotor control mechanisms in most vascular beds. Vascular TRP channels are activated by
Scott, Earley, Joseph E, Brayden
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Transient Receptor Potential Channels, the Kidney and Hypertension
Current Hypertension Reviews, 2006Smooth muscle cells as well as non-excitable cells express multiple cationic channels with significant permeability to calcium, potassium and sodium. Several of these channels are sensors of calcium store depletion, G-protein coupled receptor activation, membrane stretch, intracellular Ca2+, pH, oxidative stress, phospholipid signals and other factors.
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A transient receptor potential channel expressed in taste receptor cells
Nature Neuroscience, 2002We used differential screening of cDNAs from individual taste receptor cells to identify candidate taste transduction elements in mice. Among the differentially expressed clones, one encoded Trpm5, a member of the mammalian family of transient receptor potential (TRP) channels.
Pérez, Cristian A. +7 more
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