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Effects of chlorpyrifos on transient receptor potential channels
Toxicology Letters, 2022The well-known toxicity of chlorpyrifos (CPF) occurs via inhibition of cholinesterase (ChE), but in recent years the detrimental effects of low-dose CPF exposure have been attributed to an unknown non-cholinergic mechanism of action. We previously showed that CPF can alter gene expression of transient receptor potential canonical (TRPC) channels in ...
Wen, Li, Marion, Ehrich
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Transient Receptor Potential Channels and Mechanosensation
Annual Review of Neuroscience, 2013Transient receptor potential (TRP) channels act as sensors for a range of stimuli as diverse as light, sound, touch, pheromones, and tissue damage. Their role in mechanosensation in the animal kingdom, identified by gene ablation studies, has raised questions about whether they are directly mechanically gated, whether they act alone or in concert with ...
Niels, Eijkelkamp +2 more
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Transient receptor potential channels as therapeutic targets
Nature Reviews Drug Discovery, 2011Transient receptor potential (TRP) cation channels have been among the most aggressively pursued drug targets over the past few years. Although the initial focus of research was on TRP channels that are expressed by nociceptors, there has been an upsurge in the amount of research that implicates TRP channels in other areas of physiology and ...
Magdalene M Moran +2 more
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Transient receptor potential channels in essential hypertension
Journal of Hypertension, 2006The role of nonselective cation channels of the transient receptor potential channel (TRPC) family in essential hypertension has not yet been investigated.We studied TRPCs in 51 patients with essential hypertension and 51 age-matched and sex-matched normotensive control subjects.
Liu, Daoyan +10 more
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An overview on transient receptor potential channels superfamily
Behavioural Pharmacology, 2019The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participate in virtually every sensory ...
Merab G, Tsagareli, Ivliane, Nozadze
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Transient receptor potential channels as drug targets
Expert Opinion on Therapeutic Targets, 2007The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney.
Dayne Y, Okuhara +2 more
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Transient receptor potential channels and occupational exposure
Current Opinion in Allergy & Clinical Immunology, 2014The discovery that a number of transient receptor potential (TRP) channels are expressed in a subpopulation of primary sensory neurons innervating the upper and lower airways as well as in nonneuronal cells in the airways and lungs has initiated a quest for the understanding of their role in the physiology and pathophysiology of the respiratory tract ...
Geppetti P, Patacchini R, Nassini R.
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Transient receptor potential channels in bladder function
Acta Physiologica, 2012AbstractThe transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons.
Avelino, A. +6 more
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Transient receptor potential channels and vascular function
Clinical Science, 2010TRP (transient receptor potential) channels play important roles in the regulation of normal and pathological cellular function. In the vasculature, TRP channels are present both in ECs (endothelial cells) and vascular SMCs (smooth muscle cells) and contribute to vasomotor control mechanisms in most vascular beds. Vascular TRP channels are activated by
Scott, Earley, Joseph E, Brayden
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Transient Receptor Potential Channels on Sensory Nerves
2009The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of "thermoTRPs" TRPV1, TRPV2, TRPV3 ...
S R, Eid, D N, Cortright
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