Results 181 to 190 of about 11,254,715 (215)

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

KV channels contribute to thermal hyperaemia in skeletal muscle of humans

The Journal of Physiology, EarlyView.
Abstract figure legend Using skeletal muscle microdialysis and pulsed short‐wave diathermy, we examined the contribution of KV channels to thermal hyperaemia in human skeletal muscle. KV channel antagonism with 4‐aminopyridine attenuated thermal hyperaemia by ∼65%, identifying a critical downstream role for these ion channels in the vasodilatory ...
Ysabella I. Ruiz‐Pick, Sophia G. Wagle‐Babb, Asim Kichloo, Albert H. Olivencia‐Yurvati, Gregory M. Dick, Steven A. Romero   +5 more
wiley   +1 more source

Mechanism of Pingchuanning in Attenuating Asthma Based on UHPLC‐Q‐Orbitrap HRMS and Network Pharmacology Analysis

Biomedical Chromatography, Volume 40, Issue 12, December 2026.
ABSTRACT An ultrahigh‐performance liquid chromatography coupled with quadrupole‐Orbitrap high‐resolution mass spectrometry (UHPLC‐Q‐Orbitrap HRMS) method was applied to characterize Pingchuanning (PCN) decoction and its absorbed serum constituents in asthmatic rats.
Yue Zhang, Yiwen Ding, Weidong Chen, Yuanbo Bi, Yanyan Wang, Weidong Ye, Xiangming Fang   +6 more
wiley   +1 more source

UK Medical Cannabis Registry: A Two‐Year Prospective Observational Cohort Study of Clinical Outcomes in Insomnia

Neuropsychopharmacology Reports, Volume 46, Issue 4, December 2026.
Insomnia affects around one in ten adults. In this 2‐year UK Medical Cannabis Registry cohort study of 211 adults with insomnia, treatment with cannabis‐based medicinal products was associated with a sustained improvement in self‐reported sleep quality across 24 months.
Aran Koye, Simon Erridge, Evonne Clarke, Katy McLachlan, Ross Coomber, James J. Rucker, Mark W. Weatherall, Mikael H. Sodergren   +7 more
wiley   +1 more source

Membrane Topology and Oligomerization of Peptaibols by Solid‐State NMR Spectroscopy

Journal of Peptide Science, Volume 32, Issue 12, December 2026.
Peptaibols of 11 to 20 residues were reconstituted in lipid bilayers of varying lipid composition and investigated by solid‐state NMR spectroscopy. Their membrane alignment is revealed by 15N spectra of static‐oriented samples and their oligomerization using 19F CODEX magic angle spinning spectra. ABSTRACT Here, we review solid‐state NMR investigations
Burkhard Bechinger, Evgeniy S. Salnikov
wiley   +1 more source

Beyond monofunctionality: structural perspectives on phenol oxidase side activity in a catalase

Acta Crystallographica Section D, Volume 82, Issue 11, Page 1224-1239, November 2026.
Structural and biochemical characterization of the extracellular fungal catalase ClCPO uncovers an unexpected phenol oxidase promiscuity. Crystal structures, substrate docking and electron‐transfer pathway analysis identify ligand‐binding regions and support a working mechanistic model for catalase‐associated phenol oxidase activity.Catalases are ...
Christina Ferousi, Christos Kosinas, Odyssefs Ioannis Pantelakis, Efstratios Nikolaivits, Evangelos Topakas, Maria Dimarogona   +5 more
wiley   +1 more source

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

Single‐cell transcriptome atlas reveals a WRKY33‐HSP81 regulatory module that orchestrates phenylpropanoid‐mediated defense against Sclerotium rolfsii in Dendrobium officinale

The Plant Journal, Volume 128, Issue 3, November 2026.
SUMMARY Plants employ cell‐type‐specific transcriptional programs to defend against pathogens, yet the cellular heterogeneity of immune responses in the medicinal orchid Dendrobium officinale Kimura et Migo remains largely unexplored. A single‐cell transcriptomic atlas of the D.
Lingli Li, Ye Xu, Wei Liu, Zhitao Niu, Qingyun Xue, Xiaoyu Ding   +5 more
wiley   +1 more source

Diversity and spatial segregation of TRP channels in the closest relatives of animals. [PDF]

Proc Natl Acad Sci U S A
Mannsåker S, Burkhardt P, Colgren J.
europepmc   +1 more source