Results 61 to 70 of about 11,254,715 (215)
Advanced Science, EarlyView.Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han +11 more
wiley +1 more source
Advanced Science, EarlyView.The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma +12 more
wiley +1 more source
TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?
Membranes, 2023 Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly ...
Mayar Soussi +2 more
doaj +1 more source
Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity
Advanced Science, EarlyView.Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen +17 more
wiley +1 more source
Post-Translational Modifications of TRP Channels
Cells, 2014 Transient receptor potential (TRP) channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human.
Olaf Voolstra, Armin Huber
doaj +1 more source
REGULATION OF THE HUMAN SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3 (hTRP3) BY THE SERUM- AND GLUCOCORTICOID-INDUCED KINASE 1 (SGK1) [PDF]
Assiut Veterinary Medical Journal, 2016 The transient receptor potential channels (TRP channels) are widely expressed in a large number of various human and animal cell types. Most of the TRP channels are permeable for Ca2+ and some also for Mg2+.
HAMDY EMBARK
doaj +1 more source
Functional expression of TRPV4 channels in human collecting duct cells : implications for secondary hypertension in diabetic nephropathy [PDF]
, 2012 Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Hills, Claire E. +2 more
core +1 more source
Advanced Science, EarlyView.Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng +16 more
wiley +1 more source
Journal of Pharmacological Sciences, 2020 Cellular dielectric spectroscopy (CDS) is a novel technology enabling pharmacological evaluation of multiple receptor types with a label-free cell-based assay.
Kanako Miyano +11 more
doaj +1 more source
Advanced Science, EarlyView.Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang +11 more
wiley +1 more source