Results 111 to 120 of about 30,248 (242)

Capsaicin for neuropathic pain: linking traditional medicine and molecular biology [PDF]

, 2012
Capsaicin has long been used as a traditional medicine to treat pain and, recently, its mechanism of analgesic action has been discovered. This review article documents the clinical development of capsaicin to demonstrate that pharmacognosy still has a ...
Haanpää, Maija, Treede, Rolf-Detlef
core   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis

Mediators of Inflammation, 2018
The transient receptor potential vanilloid 1 (TRPV1) may play a role in the pathogenesis of ulcerative colitis (UC). The aim of the study was to determine the gene and protein expression of TRPV1 in UC patients and noninflamed controls.
Joel Jesús Toledo-Mauriño, Janette Furuzawa-Carballeda, Marco A. Villeda-Ramírez, Gabriela Fonseca-Camarillo, Daniela Meza-Guillen, Rafael Barreto-Zúñiga, Jesús K. Yamamoto-Furusho   +6 more
doaj   +1 more source

The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

Frontiers in Physiology, 2019
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including ...
Qian Du, Qiushi Liao, Changmei Chen, Xiaoxu Yang, Rui Xie, Jingyu Xu   +5 more
doaj   +1 more source

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat [PDF]

, 2016
Background: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic ...
A Dickenson, A Hasani, A Morita, A Szabo, A Szallasi, A Tóth, AC Barrett, D Melck, D Ursu, DR Sagar, FN McNamara, G Woolfe, GY Wong, H Xu, J Hoffmann, JB Davis, JR Ghilardi, JR Saper, L Bach-Rojecky, L Petrocellis De, L Yang, M Alsalem, M Cantillon, M Caterina, M Tominaga, M-G Lee, MDM Wallace, MJ Caterina, MJ Gunthorpe, N Kedei, NR Gavva, P Anand, PA Koplas, PE Micevych, PJ Millns, R Docherty, RM Lindsay, S Diamond, S Mandadi, SR Eid, T Christoph, T Rosenbaum, V Marzo Di, Z Vogel   +43 more
core   +2 more sources

Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels, Orai1 and TRPV3

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To examine the effects of Tribulus terrestris L. (T. terrestris) extract on the modulation of calcium channels to evaluate its use in topical agents for treatment of atopic dermatitis. Methods: The 70% methanol extract of T.
Joo Hyun Nam, Hyo Won Jung, Young-Won Chin, Woo Kyung Kim, Hyo Sang Bae   +4 more
doaj   +1 more source

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia [PDF]

, 2004
Inflammatory proteases (mast cell tryptase and trypsins) cleave protease-activated receptor 2 (PAR2) on spinal afferent neurons and cause persistent inflammation and hyperalgesia by unknown mechanisms.
Amadesi, Silvia, Bunnett, N. W., Cottrell, Graeme S., Davis, J. B., Ennes, H., Geppetti, P., Grady, E. F., Manni, C., Mayer, E. A., McRoberts, J. A., Nie, J., Trevisani, M., Vergnolle, N.   +12 more
core   +1 more source

Transient Hyperparathyroidism and Severe Intrauterine Osteopenia Linked to Novel Homozygous TRPV6 Deletion

Clinical Endocrinology, EarlyView.
ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore, Quinty Leusink, Femke Latta, Bram van der Eerden, Paul de Laat, Danielle van der Kaay, Joost Hoenderop   +6 more
wiley   +1 more source

Modulation of TRPV1 on Odontoblast-like Cells Using Capsazepine-Loaded Nanogels

Pharmaceutics
The modulation of TRPV1 emerges as a promising strategy for dental pain management. This study aimed to assess TRPV1 modulation in a human odontoblast-like cell model using Capsazepine (CZP) loaded in a nanogel delivery system.
Lilia Jadith Bernal-Cepeda, Ronald Andrés Jiménez, Myriam L. Velandia-Romero, Paola Acosta-Guzmán, Jaime E. Castellanos   +4 more
doaj   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source