Results 121 to 130 of about 30,248 (242)

CB1 Cannabinoid Receptor Stimulation Modulates Transient Receptor Potential Vanilloid Receptor 1 Activities in Calcium Influx and Substance P Release in Cultured Rat Dorsal Root Ganglion Cells

Journal of Pharmacological Sciences, 2005
Cannabinoids have been reported to have analgesic properties in animals of acute nociception or of inflammatory and neuropathic pain models, but the mechanisms by which they exert such alleviative effects are not yet fully understood.
Kyoko Oshita, Atsuko Inoue, He-Bin Tang, Yoshihiro Nakata, Masashi Kawamoto, Osafumi Yuge   +5 more
doaj   +1 more source

Non‐Pharmacological Interventions for Cough in Patients With Lung Cancer: A Systematic Review and Meta‐Analysis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background Cough, a prevalent and debilitating symptom of lung cancer, remains poorly managed. Accumulating evidence on non‐pharmacological interventions for lung cancer cough necessitates systematic evaluation to assess their efficacy. Aim To synthesise evidence on non‐pharmacological interventions for managing cough in lung cancer patients ...
Mengyao Cao, Xueyan Cheng, Victor Ho‐fun Lee, Chia‐Chin Lin, Denise Shuk Ting Cheung   +4 more
wiley   +1 more source

Demonstration of ovarian and brain tissue interactions as a result of stimulation of oogenesis in Migraine Modeled rats.

Revista Científica
Migraine, is a primary neurological disease. Although there is no gender difference in the prepubertal period, migraine is more common in adult women than in adult men. This situation decreases with menopause, but still its dominance in women continues.
Berna Özdenoğlu-Kutlu, Serpi Ünver-Saraydin   +1 more
doaj   +1 more source

Local Administration of a Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Inflammatory Pain in Rats

Journal of Pharmacological Sciences, 2010
Novel agents that inhibit nerve growth factor signaling are required for the treatment of inflammatory pain. The present study investigated the effect of local administration of inhibitory peptide of TrkA (IPTRK3), a synthetic cell-penetrating peptide ...
Koyo Ueda, Munetaka Hirose, Eri Murata, Mayumi Takatori, Masashi Ueda, Hiroshi Ikeda, Kenji Shigemi   +6 more
doaj   +1 more source

Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial

Journal of Oral Rehabilitation, EarlyView.
We investigated the effects of combined transcranial direct current stimulation (tDCS) and oral capsaicinoids on swallowing function in 21 healthy young adults. The combined cortical and peripheral sensory intervention could potentially facilitate swallowing.
Ivy Cheng, Sonja Suntrup‐Krüger
wiley   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source