Results 141 to 150 of about 23,801 (234)

Attenuation of senile pruritus by PAC-14028-mediated downregulation of the NF-κB and MAPK pathways

International Journal of Immunopathology and Pharmacology
Objective: Senile pruritus is a specific type of itching that occurs in elderly persons. Previously, we assessed antagonism of the nonselective ligand-gated cation channel transient receptor potential vanilloid 1 (TRPV1; capsaicin receptor or vanilloid ...
Ji Hye Yoon, Byoung Young Woo, Mi-Yeon Kim, Jae Youl Cho   +3 more
doaj   +1 more source

pH‐Shift‐Prepared Chlorella pyrenoidosa Protein/Peptide–Calcium Complexes Improve Skeletal Health by Enhanced Intestinal Calcium Utilization in Calcium‐Deficient Rats

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Calcium carbonate supplements often exhibit limited solubility and gastrointestinal precipitation, restricting calcium availability. To address this limitation, an enzyme‐free pH‐shift strategy was applied to prepare Chlorella pyrenoidosa protein (CPP)/peptide–calcium complexes (pH–Ca) and to evaluate their effects on calcium utilization in ...
Yan Yang, Shenwan Wang, Qimeng Zhou, Ye Qi, Bin Zhou, Jing Li, Tao Hou, Bin Li, Hongshan Liang   +8 more
wiley   +1 more source

Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Single‐cell mechanical properties such as stiffness, elasticity, and viscosity, are crucial in governing biological processes like migration, proliferation, and differentiation. In cancer, the mechanical properties of cells undergo significant alterations, which contribute to tumor growth, metastasis, and resistance to therapy.
Merve Sevgi, Yağmur Işık, Caner Karaca, Esmahan Çağlar, Hasan Berkay Abdioğlu, Ferican Zendel, Yasemin Başbınar, Hüseyin Üvet   +7 more
wiley   +1 more source

Management of suspected opioid‐induced hyperalgesia in a dog

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract Opioid‐induced hyperalgesia is a recognised phenomenon in people, but few cases are described in veterinary patients. This case reports a dog with suspected opioid‐induced hyperalgesia after a stick injury to the mouth and neck, and subsequent surgical exploration of the ventral neck and abscess debridement.
Robin Stallard, Daniel Lomas, Julia Deutsch   +2 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1181-1192, May 2026.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source

Animal Models of Hunner‐Type Interstitial Cystitis

International Journal of Urology, Volume 33, Issue 5, May 2026.
ABSTRACT Background Animal models are crucial for mechanistic studies and therapeutic development of human diseases. At present, the etiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic disease of the urinary bladder, remains undefined.
Yoshiyuki Akiyama, Yi Luo
wiley   +1 more source

Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Emanuel F. Matias, Francisco M. Vila‐Real, Maria A. Vieira‐Coelho   +2 more
wiley   +1 more source

Identification of Cardiac Expression Pattern of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Receptor using a Transgenic Reporter Mouse Model. [PDF]

Neurosci Lett, 2020
Hong J, Lisco AM, Rudebush TL, Yu L, Gao L, Kitzerow O, Zucker IH, Wang HJ.   +7 more
europepmc   +1 more source

Polymodal TRPV1 and TRPV4 sensors colocalize but do not functionally interact in a subpopulation of mouse retinal ganglion cells [PDF]

, 2018
Baumann, Jackson M, Hu, Hongzhen, Jo, Andrew O, Krizaj, David, Lakk, Monika, Young, Derek   +5 more
core   +2 more sources