Results 221 to 230 of about 3,188,460 (275)

Deep‐Learning‐Based Denoising for Improved Phase Precision in Electron Holography of Electromagnetic Fields in Nanoscale Materials

Advanced Science, EarlyView.
Low‐dose electron holography is limited by shot noise, which buries weak phase signals. HoloDenoiser, a physics‐informed network that works simultaneously in the spatial and frequency domains, locates and protects the holographic sideband while suppressing noise in the hologram.
Ye Luo, Luyang Wang, Zhiling Yu, Xiaowen Chen, Xiaoyu Wang, Ya‐Hui Jia, Thibaud Denneulin, Yu Han, Rafal E. Dunin‐Borkowski, Fengshan Zheng, Qi Liu   +10 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

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Shocks to Transition Risk

SSRN Electronic Journal, 2020
We propose a robust and comprehensive method to identify shocks to transition risk emerging from the shift towards a carbon-neutral economy. We apply it to the US, UK, and Germany and find that various types of events constitute shocks to transition risk.
Christoph Meinerding, Yves S. Schüler, Philipp Zhang   +2 more
openaire   +2 more sources

Credit Transition and Structural Shocks

The Quarterly Journal of Finance, 2021
Credit risk involves not only the complexity of screening but also monitoring and estimating rating transition. The adoption of inadequate transition matrices causes a misevaluation of credit risk, a consequent misallocation of capital, with the prospect that the lending process will be affected by increasing transaction costs and limited rationality ...
Camilla Ferretti, Giampaolo Gabbi, Piero Ganugi, Pietro Vozzella   +3 more
openaire   +1 more source

THE SHOCK-TO-DETONATION TRANSITION IN SOLID EXPLOSIVES

Symposium (International) on Combustion, 1963
The development of a shock wave and its subsequent growth-to-detonation is considered to be a necessary step in the initiation of detonation in any explosive. Using this argument as a basis, it is logical to study in detail, the development of impulse-initiated detonations, to establish the dependence of the growth-to-detonation process on physical ...
S.J. Jacobs, T.P. Liddiard, B.E. Drimmer
openaire   +1 more source

Morin transition of shock-modified hematite

Physical Review B, 1986
Hematite (\ensuremath{\alpha}-${\mathrm{Fe}}_{2}$${\mathrm{O}}_{3}$) powder compacts have been subjected to controlled, quantitative high-pressure shock loading at peak pressures from 8 to 27 GPa and preserved for postshock analysis. Analysis of broadened x-ray line profiles shows a reduction of average crystallite size to about 60 nm and retained ...
, Williamson, , Venturini, , Graham, , Morosin   +3 more
openaire   +2 more sources