Results 1 to 10 of about 287,723 (142)
Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells [PDF]
eLifeTranslation initiation in eukaryotes requires a 40 S ribosome loaded with initiator tRNA which scans for an initiation codon. The initiator tRNA is usually recruited to the ribosome as part of a ternary complex composed of initiator tRNA, eIF2, and GTP ...
Mykola Roiuk +2 more
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NetStart 2.0: prediction of eukaryotic translation initiation sites using a protein language model [PDF]
BMC BioinformaticsBackground Accurate identification of translation initiation sites is essential for the proper translation of mRNA into functional proteins. In eukaryotes, the choice of the translation initiation site is influenced by multiple factors, including its ...
Line Sandvad Nielsen +3 more
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Transcriptome-wide mapping of small ribosomal subunits elucidates scanning mechanisms of translation initiation in the mammalian brain [PDF]
Communications BiologyNeuronal protein synthesis is highly compartmentalised and regulated, with key roles for translation initiation and elongation factors. Ribosome profiling, the most widely used transcriptome-wide method for measuring translation, captures translation ...
Preeti Madhav Kute +4 more
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Unnatural Translation Initiation [PDF]
ACS Chemical Biology, 2008 Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids.
John W, Tomsho, Stephen J, Benkovic
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Scientific Reports, 2021 Cap-independent translation initiation plays crucial roles in fine-tuning gene expression under global translation shutdown conditions. Translation of uncapped or de-capped transcripts can be stimulated by Cap-independent translation enhancer (CITE ...
Brandon M. Trainor +4 more
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Proteostasis is differentially modulated by inhibition of translation initiation or elongation
eLife, 2023 Recent work has revealed an increasingly important role for mRNA translation in maintaining proteostasis. Here, we use chemical inhibitors targeting discrete steps of translation to compare how lowering the concentration of all or only translation ...
Khalyd J Clay +3 more
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Zdorovʹe Rebenka, 2022 The scientific review considers the mechanisms of action of cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during the initiation and post-initiation period of translation.
A.E. Abaturov, V.L. Babуch
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PLoS ONE, 2022 A number of neurologic diseases associated with expanded nucleotide repeats, including an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation called repeat-associated non-AUG (RAN) translation.
Alec C Gleason +4 more
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The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
PLoS ONE, 2023 Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with ...
Marina P Volegova +2 more
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Leveraging genome-wide datasets to quantify the functional role of the anti-Shine–Dalgarno sequence in regulating translation efficiency [PDF]
Open Biology, 2017 Studies dating back to the 1970s established that sequence complementarity between the anti-Shine–Dalgarno (aSD) sequence on prokaryotic ribosomes and the 5′ untranslated region of mRNAs helps to facilitate translation initiation. The optimal location of
Adam J. Hockenberry +3 more
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