Results 11 to 20 of about 287,743 (162)
A translation initiation element specific to mRNAs with very short 5'UTR that also regulates transcription. [PDF]
PLoS ONE, 2008 Transcription is controlled by cis regulatory elements, which if localized downstream to the transcriptional start site (TSS), in the 5'UTR, could influence translation as well.
Rofa Elfakess, Rivka Dikstein
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Non-AUG translation initiation in mammals
Genome Biology, 2022 Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA.
Dmitry E. Andreev +5 more
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Modifications on Translation Initiation [PDF]
Cell, 2015 Two studies by Meyer et al. and Wang et al. demonstrate a role for m(6)A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes.
Mitchell, Sarah F., Parker, Roy
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eLife, 2016 Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown.
Ryuta Ishimura +4 more
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Translation initiation of viral mRNAs [PDF]
Reviews in Medical Virology, 2010 AbstractViruses depend on cells for their replication but have evolved mechanisms to achieve this in an efficient and, in some instances, a cell‐type‐specific manner. The expression of viral proteins is frequently subject to translational control. The dominant target of such control is the initiation step of protein synthesis.
Lopez-Lastra, Marcelo +5 more
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Reversal of G-Quadruplexes’ Role in Translation Control When Present in the Context of an IRES
Biomolecules, 2022 G-quadruplexes (GQs) are secondary nucleic acid structures that play regulatory roles in various cellular processes. G-quadruplex-forming sequences present within the 5′ UTR of mRNAs can function not only as repressors of translation but also as elements
Mohammed Enamul Hoque +2 more
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Sulfolobus solfataricus translation initiation factor 1 stimulates translation initiation complex formation [PDF]
RNA, 2006 The eukaryotic translation initiation factor 1 binds to the ribosome during translation initiation. It is instrumental for initiator-tRNA and mRNA binding, and has a function in selection of the authentic start codon. Here, we show that the archaeal homolog aIF1 has analogous functions.
D. Hasenohrl +4 more
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Frontiers in Plant Science, 2019 MATH-BTB proteins are known to act as substrate-specific adaptors of CUL3-based E3 ligases in the ubiquitin proteasome pathway. Their BTB domain binds to CUL3 scaffold proteins and the less conserved MATH domain targets a highly diverse collection of ...
Nataša Bauer +9 more
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Promotion of Viral IRES-Mediated Translation Initiation under Mild Hypothermia. [PDF]
PLoS ONE, 2015 Internal ribosome entry site (IRES)-mediated translation is an essential replication step for certain viruses. As IRES-mediated translation is regulated differently from cap-dependent translation under various cellular conditions, we sought to ...
Maria Licursi +3 more
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Cell Reports, 2019 Summary: Sequences within 5′ UTRs dictate the site and efficiency of translation initiation. In this study, an unbiased screen designed to interrogate the 5′ UTR-mediated regulation of the growth-promoting gene MYC unexpectedly revealed the ribosomal ...
Hema Manjunath +5 more
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