Results 21 to 30 of about 287,743 (162)
Eukaryotic translation initiation factors and cancer
Tumor Biology, 2017 Recent technological advancements have shown tremendous mechanistic accomplishments in our understanding of the mechanism of messenger RNA translation in eukaryotic cells.
Muhammad Umar Ali +3 more
doaj +1 more source
Virology Journal, 2011 Background Porcine reproductive and respitatory syndrome virus (PRRSV) is a recently emerged pathogen and severely affects swine populations worldwide.
Dou Yong-xi +7 more
doaj +1 more source
Regulation of Leaderless mRNA Translation in Bacteria
Microorganisms, 2022 In bacteria, the translation of genetic information can begin through at least three different mechanisms: canonical or Shine-Dalgarno-led initiation, readthrough or 70S scanning initiation, or leaderless initiation.
Lorenzo Eugenio Leiva, Assaf Katz
doaj +1 more source
Local absence of secondary structure permits translation of mRNAs that lack ribosome-binding sites. [PDF]
PLoS Genetics, 2011 The initiation of translation is a fundamental and highly regulated process in gene expression. Translation initiation in prokaryotic systems usually requires interaction between the ribosome and an mRNA sequence upstream of the initiation codon, the so ...
Lars B Scharff +3 more
doaj +1 more source
Cells, 2021 mRNA secondary structure influences translation. Proteins that modulate the mRNA secondary structure around the translation initiation region may regulate translation in plastids.
Piotr Gawroński +8 more
doaj +1 more source
mTOR, translation initiation and cancer [PDF]
Oncogene, 2006 Control of mRNA translation plays a fundamental role in many aspects of cell metabolism. It constitutes a critical step in the control of gene expression, and consequently cell growth, proliferation and differentiation. Translation is regulated in response to nutrient availability, hormones, mitogenic and growth factor stimulation and is coupled with ...
Mamane, Y +3 more
openaire +4 more sources
Comparison of computational methods for identifying translation initiation sites in EST data
BMC Bioinformatics, 2004 Background Expressed Sequence Tag (EST) sequences are generally single-strand, single-pass sequences, only 200–600 nucleotides long, contain errors resulting in frame shifts, and represent different parts of their parent cDNA.
Ellis Lynda BM +2 more
doaj +1 more source
RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation
Viruses, 2022 Viruses are obligate intracellular parasites that depend on the host’s protein synthesis machinery for translating their mRNAs. The viral mRNA (vRNA) competes with the host mRNA to recruit the translational machinery, including ribosomes, tRNAs, and the ...
Brenda López-Ulloa +3 more
doaj +1 more source
Cell Reports, 2018 Summary: Protein translation in eukaryotes is cell-cycle dependent, with translation rates more robust in G1 phase of the cell cycle than in mitosis. However, whether the fundamental cell-cycle control machinery directly activates protein translation ...
Tai An +4 more
doaj +1 more source
Profiling of Small Ribosomal Subunits Reveals Modes and Regulation of Translation Initiation
Cell Reports, 2020 Summary: Translation initiation is often attributed as the rate-determining step of eukaryotic protein synthesis and key to gene expression control. Despite this centrality, the series of steps involved in this process is poorly understood.
Adam Giess +8 more
doaj +1 more source