Results 31 to 40 of about 287,743 (162)
Bypassing Translation Initiation [PDF]
Structure, 2007 A high-resolution cryo-EM reconstruction of a ribosome-bound dicistrovirus IRES (Schüler et al., 2006) and the crystal structure of its ribosome binding domain (Pfingsten et al., 2006) provide new insights into an exceptional eukaryotic translation mechanism.
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Noncanonical Translation Initiation in Eukaryotes [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The vast majority of eukaryotic messenger RNAs (mRNAs) initiate translation through a canonical, cap-dependent mechanism requiring a free 5' end and 5' cap and several initiation factors to form a translationally active ribosome. Stresses such as hypoxia, apoptosis, starvation, and viral infection down-regulate cap-dependent translation during which ...
Thaddaeus, Kwan, Sunnie R, Thompson
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Synaptic Plasticity and Translation Initiation [PDF]
Learning & Memory, 2004 It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA.
Eric, Klann +3 more
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Exploration of Targeted Anti-tumor Therapy, 2020 Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins.
Joe Taylor +2 more
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Synonymous codon usage regulates translation initiation
Cell Reports, 2023 Summary: Nonoptimal synonymous codons repress gene expression, but the underlying mechanisms are poorly understood. We and others have previously shown that nonoptimal codons slow translation elongation speeds and thereby trigger messenger RNA (mRNA ...
Chloe L. Barrington +7 more
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BiomoleculesTranslation initiation in mitochondria involves unique mechanisms distinct from those in the cytosol or in bacteria. The Schizosaccharomyces pombe mitochondrial translation initiation factor 2 (Mti2) is the ortholog of human MTIF2, which plays a vital ...
Ying Luo, Jürg Bähler, Ying Huang
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Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.
PLoS ONE, 2013 Protein synthesis is mainly regulated at the initiation step, allowing the fast, reversible and spatial control of gene expression. Initiation of protein synthesis requires at least 13 translation initiation factors to assemble the 80S ribosomal ...
Giuseppe Fiume +13 more
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Comprehensive profiling of translation initiation in influenza virus infected cells.
PLoS Pathogens, 2019 Translation can initiate at alternate, non-canonical start codons in response to stressful stimuli in mammalian cells. Recent studies suggest that viral infection and anti-viral responses alter sites of translation initiation, and in some cases, lead to ...
Heather M Machkovech +2 more
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Pathogens, 2017 Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional ...
Eden R. Freire +3 more
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Cap-dependent translation initiation monitored in living cells
Nature Communications, 2022 mRNA translation is tightly regulated to preserve cellular homeostasis. Here live-cell spectroscopy and single-particle tracking are combined to interrogate the binding dynamics of endogenous initiation factors to mRNAs 5’cap, revealing the sequence of ...
Valentina Gandin +7 more
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