Results 41 to 50 of about 287,743 (162)
Recent Advances in Archaeal Translation Initiation
Frontiers in Microbiology, 2020 Translation initiation (TI) allows accurate selection of the initiation codon on a messenger RNA (mRNA) and defines the reading frame. In all domains of life, translation initiation generally occurs within a macromolecular complex made up of the small ...
Emmanuelle Schmitt +5 more
doaj +1 more source
Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis
European Respiratory Review, 2023 Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of rapamycin complex 1 (mTORC1) pathway.
Jilly F. Evans +3 more
doaj +1 more source
Universally conserved translation initiation factors
Proceedings of the National Academy of Sciences, 1998 The process by which translation is initiated has long been considered similar in Bacteria and Eukarya but accomplished by a different unrelated set of factors in the two cases. This not only implies separate evolutionary histories for the two but also implies that at the universal ancestor stage, a translation initiation mechanism either ...
N C, Kyrpides, C R, Woese
openaire +3 more sources
mBioDiverse microbial pathogens are known to attenuate host protein synthesis. Consequently, the host mounts a defense response against protein translation inhibition, leading to increased transcript levels of immune genes.
Annesha Ghosh, Jogender Singh
doaj +1 more source
Universal scanning-free initiation of eukaryote protein translation–a new normal
Biomolecular Concepts, 2021 A unique feature of eukaryote initiation of protein translation is a so-called scanning of 5′-untranslated region (5′-UTR) by a ribosome initiation complex to enable bound Met-tRNAi access to the initiation codon located further downstream.
Auparakkitanon Saranya, Wilairat Prapon
doaj +1 more source
Neurobiology of Disease, 2023 Neurodegeneration in Fragile X-associated tremor/ataxia syndrome (FXTAS) is caused by a CGG trinucleotide repeat expansion in the 5′ UTR of FMR1. Expanded CGG repeat RNAs form stable secondary structures, which in turn support repeat-associated non-AUG ...
Indranil Malik +6 more
doaj +1 more source
Distinct pre-initiation steps in human mitochondrial translation
Nature Communications, 2020 Translation within mitochondria relies upon specialized mitoribosomes and initiation factors. Here the authors use Cryo-EM and single molecule approaches to describe the early steps leading to translation initiation in human mitochondria, and the roles ...
Anas Khawaja +7 more
doaj +1 more source
4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression
Viruses, 2016 West Nile virus (WNV) is a (+) sense, single-stranded RNA virus in the Flavivirus genus. WNV RNA possesses an m7GpppNm 5′ cap with 2′-O-methylation that mimics host mRNAs preventing innate immune detection and allowing the virus to translate its RNA ...
Katherine D. Shives +4 more
doaj +1 more source
IRES-dependent translational control during virus-induced endoplasmic reticulum stress and apoptosis
Frontiers in Microbiology, 2012 Many virus infections and stresses can induce endoplasmic reticulum (ER) stress response, a host self defense mechanism against viral invasion and stress.
Paul eHanson +5 more
doaj +1 more source
Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]
The EMBO Journal, 2013 Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias. Although recent studies have shown strong effects of codon usage changes on protein expression levels and cellular physiology, no translational ...
Chu, Dominique +5 more
openaire +2 more sources