Results 51 to 60 of about 287,743 (162)
PLoS ONEProtein synthesis involves translation initiation, elongation, termination, and ribosome recycling, and each step is controlled intricately by many signaling proteins.
Guturu L Harika, Krishnamachari Sriram
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Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression
Journal of Nucleic Acids, 2016 Protein synthesis can be segmented into distinct phases comprising mRNA translation initiation, elongation, and termination. Translation initiation is a highly regulated and rate-limiting step of protein synthesis that requires more than 12 eukaryotic ...
Divya Khandige Sharma +4 more
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BMC Bioinformatics, 2007 Background The nucleotide sequence flanking the translation initiation codon (start codon context) affects the translational efficiency of eukaryotic mRNAs, and may indicate the presence of an alternative translation initiation site (TIS) to produce ...
Menossi Marcelo, Vicentini Renato
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Self-Initiation of Translation of mRNAs Devoid of Translational Initiators in Escherichia coli
Folia Biologica, 2001 Recent studies have shown that the canonical SD-anti-SD interaction is dispensable for the initiation of translation of certain mRNAs in Escherichia coli. In this study the cat and tetR genes were modified to either destroy complementarity to E. coli 16S RNA or completely delete their 5' non-translated regions.
V, Kolev, A, Berzal-Herranz, I, Ivanov
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MetWAMer: eukaryotic translation initiation site prediction
BMC Bioinformatics, 2008 Background Translation initiation site (TIS) identification is an important aspect of the gene annotation process, requisite for the accurate delineation of protein sequences from transcript data. We have developed the MetWAMer package for TIS prediction
Brendel Volker, Sparks Michael E
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Expression and clinical value of EIF3CL in serous ovarian cancer
Journal of International Medical ResearchObjectives This study aimed to explore the expression of eukaryotic translation initiation factor 3 subunit C-like in serous ovarian cancer samples (both paraffin-embedded and fresh samples) and evaluate its clinical value in patients with serous ovarian
Tingting Li +6 more
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Ribosome signatures aid bacterial translation initiation site identification
BMC Biology, 2017 Background While methods for annotation of genes are increasingly reliable, the exact identification of translation initiation sites remains a challenging problem.
Adam Giess +5 more
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Inverted translational control of eukaryotic gene expression by ribosome collisions.
PLoS Biology, 2019 The canonical model of eukaryotic translation posits that efficient translation initiation increases protein expression and mRNA stability. Contrary to this model, we find that increasing initiation rate can decrease both protein expression and stability
Heungwon Park, Arvind R Subramaniam
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A threonyl-tRNA synthetase-mediated translation initiation machinery
Nature Communications, 2019 The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate ...
Seung Jae Jeong +18 more
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Optimizing Phage Translation Initiation
OBM Genetics, 2019 Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiation, elongation and termination, with translation ...
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