Results 41 to 50 of about 409,300 (260)

Tracking the performance of an R&D programme in the biomedical sciences [PDF]

, 2016
Pre-refereed version of manuscript accepted for publication in Research EvaluatioN: arXiv:1602.04049This article aims at offering an evaluation framework of an R&D programme in the biomedical sciences.
Cabezas-Clavijo, Álvaro, Jiménez-Contreras, Evaristo, Robinson-García, Nicolás   +2 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Making translational value: Identifying ‘good targets’ for clinical research on gene editing and induced pluripotent stem cell technologies

SSM: Qualitative Research in Health, 2022
Biomedical translational researchers aim to develop knowledge and techniques arising from research in the life sciences into clinical applications. Using the examples of induced pluripotent stem cells (iPSC) and gene editing, this paper examines how ...
Michael Morrison, Andrew Bartlett
doaj   +1 more source

Translational Oncogenomics and Human Cancer Interactome Networks [PDF]

, 2011
An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology.
I. C. Baianu
core   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Translational Research from an Informatics Perspective [PDF]

, 2007
Clinical and translational research (CTR) is an essential part of a sustainable global health system. Informatics is now recognized as an important en-abler of CTR and informaticians are increasingly called upon to help CTR efforts.
Bernstam, Elmer, Johnson-Throop, Kathy A., Meric-Bernstam, Funda, Smith, Jack W., Turley, James P.   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Knowledge Production and Transfer in the Iranian Oral Health Research Centers: Based on Research Evaluation from 2019 to 2021

Frontiers in Dentistry
Due to the global burden of oral diseases, knowledge production and transfer are essential for clinical practice and policy. This descriptive study assessed 28 Iranian Oral Health Research Centers (OHRCs) from 13 medical universities (2019–2021), using ...
Katayoun Falahat, Monir Baradaran Eftekhari, Aboozar Ramezani   +2 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source