Results 31 to 40 of about 29,448 (249)
Tumor Transplantation to the Subdural Space of Heterologous Hosts.
Experimental Biology and Medicine, 1951 SummaryMouse Sarcoma 37 was transplanted to the subdural space of 14 guinea pigs. Evidence of growth was present in all animals sacrificed between the 2nd and 18th day after transplantation. One animal died at the end of the third week, apparently as the result of invasion of the brain by tumor tissue.
H. Y. Chang +2 more
openaire +3 more sources
A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules
Advanced Science, EarlyView.Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang +6 more
wiley +1 more source
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance
Frontiers in Immunology, 2012 Adaptive immunity in both mouse and man results in the generation of immunological memory. Memory T cells are both friend and foe to transplant recipients, as they are intimately involved and in many cases absolutely required for the maintenance of ...
Scott M. Krummey, Mandy L Ford
doaj +1 more source
A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age [PDF]
, 2016 There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female
Goya, Rodolfo Gustavo +4 more
core +1 more source
Advanced Science, EarlyView.The CtrCBL1‐CtrCIPK6 module of trifoliate orange (Citrus trifoliata L.) phosphorylates CtrBBX32, triggering its protein degradation under cold conditions, thereby relieving CtrBBX32‐mediated transcriptional repression of CtrZAT10 and CtrSTP1. The consequent upregulation of CtrZAT10 further activates CtrSTP1 expression, which enhances hexose transport ...
Xiangming Shang +10 more
wiley +1 more source
Human islet xenotransplantation in rodents: A literature review of experimental model trends
ClinicsAmong the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low
Leandro Ryuchi Iuamoto +10 more
doaj +1 more source
The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts
Frontiers in Immunology, 2018 The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor ...
Johannes Baur +12 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Type 1 diabetes mellitus (T1DM) is an autoimmune disorder specifically targeting pancreatic islet beta cells. Despite many efforts focused on identifying new therapies able to counteract this autoimmune attack and/or stimulate beta cells regeneration ...
C. C. Lachaud +16 more
doaj +1 more source
Heterologous spinal cord transplantation in man [PDF]
Surgical Neurology International, 2021 Sergio Canavero +2 more
openaire +2 more sources
Parabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source