Results 31 to 40 of about 28,513 (235)

Unveiling Salt Tolerance Mechanisms in Plants: Integrating the KANMB Machine Learning Model With Metabolomic and Transcriptomic Analysis

Advanced Science, EarlyView.
Salt stress endangers coastal cereal crops, requiring resilient crop solutions. This study employs machine learning (KANMB) to analyze multi‐omics data from halophyte Spartina alterniflora, revealing 226 salt‐stress biomarkers and linking them to tolerance pathways. The MYB gene SaMYB35 regulates flavonoid biosynthesis under salinity.
Shoukun Chen, Hao Zhang, Shuqiang Gao, Kunhui He, Tingxi Yu, Shang Gao, Jiankang Wang, Huihui Li   +7 more
wiley   +1 more source

Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation

mBio, 2016
Bacterial communities from subjects treated for recurrent Clostridium difficile infection (rCDI) by fecal microbiota transplantation (FMT), using either heterologous donor stool samples or autologous stool samples, were characterized by Illumina next ...
Christopher Staley, Colleen R. Kelly, Lawrence J. Brandt, Alexander Khoruts, Michael J. Sadowsky   +4 more
doaj   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Heterogeneity within T Cell Memory: Implications for Transplant Tolerance

Frontiers in Immunology, 2012
Adaptive immunity in both mouse and man results in the generation of immunological memory. Memory T cells are both friend and foe to transplant recipients, as they are intimately involved and in many cases absolutely required for the maintenance of ...
Scott M. Krummey, Mandy L Ford
doaj   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Human islet xenotransplantation in rodents: A literature review of experimental model trends

Clinics
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low
Leandro Ryuchi Iuamoto, André Silva Franco, Fábio Yuji Suguita, Felipe Futema Essu, Lucas Torres Oliveira, Juliana Mika Kato, Matheus Belloni Torsani, Alberto Meyer, Wellington Andraus, Eleazar Chaib, Luiz Augusto Carneiro D’Albuquerque   +10 more
doaj   +1 more source

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

Frontiers in Immunology, 2018
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor ...
Johannes Baur, Christoph Otto, Ulrich Steger, Stefan Klein-Hessling, Khalid Muhammad, Tobias Pusch, Krisna Murti, Rhoda Wismer, Christoph-Thomas Germer, Ingo Klein, Nora Müller, Edgar Serfling, Andris Avots   +12 more
doaj   +1 more source

Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses

Frontiers in Cell and Developmental Biology, 2023
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder specifically targeting pancreatic islet beta cells. Despite many efforts focused on identifying new therapies able to counteract this autoimmune attack and/or stimulate beta cells regeneration ...
C. C. Lachaud, N. Cobo-Vuilleumier, E. Fuente-Martin, I. Diaz, E. Andreu, E. Andreu, G. M. Cahuana, G. M. Cahuana, J. R. Tejedo, J. R. Tejedo, A. Hmadcha, A. Hmadcha, B. R. Gauthier, B. R. Gauthier, B. Soria, B. Soria, B. Soria   +16 more
doaj   +1 more source

Heterologous spinal cord transplantation in man [PDF]

Surgical Neurology International, 2021
Sergio Canavero, C-Yoon Kim, Xiaoping Ren   +2 more
openaire   +2 more sources

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source